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US 2023/0098752 A1Published application
Cocoa polyphenols and soluble dietary fiber for use in the treatment or prevention disorders associated with an above-normal number of granulocytes in a tissue
AssigneeSociete des Produits Nestle S.A.
InventorsCarine Blanchard, Sebastien Holvoet, Rinat Ran-Ressler, Martinas Kuslys
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Abstract
The present invention relates to a composition comprising at least one cocoa polyphenol and soluble dietary fiber for use in the prevention or treatment of a disorder associated with an above-normal number of granulocytes in a tissue.
Claims20
1:
- A method of prevention or treatment of at least one disorder selected from the group consisting of an allergy, a gastrointestinal syndrome, lung allergic inflammation, and skin atopic dermatitis, the method comprising administering a composition comprising at least one cocoa polyphenol and at least one fermentable dietary fiber to an individual in need thereof.
2:
- The method of claim 1, wherein the allergy is associated with food or an aeroallergen.
3:
- The method of claim 2, wherein the allergy associated with aeroallergen is at least one of asthma or allergic rhinitis.
4:
- The method of claim 1, wherein the composition further comprises a source of protein.
5:
- The method of claim 4, wherein the protein is selected from the group consisting of potato protein, rice protein, legume proteins, millet, quinoa, lupin, canola, tapioca, and mixtures thereof.
6:
- The method of claim 1, wherein the at least one cocoa polyphenol comprises a procyanidin selected from the group consisting of (i) procyanidin B1;
- (ii) procyanidin B2;
- (iii) a procyanidin not being procyanidin B1 or B2;
- (iv) one or more multimers of procyanidin B1, procyanidin B2, or a procyanidin not being B1 or B2, the multimer being any of a 2-mer to a 10-mer;
- and (v) mixtures thereof.
2 more elements
7:
- The method of claim 1, wherein (a) the at least one cocoa polyphenol comprises at least one of procyanidin B1 or a multimer of procyanidin B1, and the at least one of procyanidin B1 or a multimer of procyanidin B1 is 0.01 wt. % to 0.5 wt. % of the composition;
- or
- (b) the at least one cocoa polyphenol comprises at least one of procyanidin B2 or a multimer of procyanidin B2, and the at least one of procyanidin B2 or a multimer of procyanidin B2 is is 0.01 wt. % to 1.0% wt. % of the composition.
8:
- The method of claim 1, wherein the at least one cocoa polyphenol comprises at least one of a procyanidin not being either procyanidin B1 or B2 or a multimer of a procyanidin not being either procyanidin B1 or B2, and the at least one of a procyanidin not being either procyanidin B1 or B2 or a multimer of a procyanidin not being either procyanidin B1 or B2 is 0.5 wt. % to 10 wt. % of the composition.
9:
- The method of claim 1, wherein the at least one cocoa polyphenol comprises epicatechin that is 0.01 wt. % to 0.5 wt. % of the composition.
10:
- The method of claim 1, wherein the composition is administered to the individual orally, topical-orally, or as a spray.
11:
- The method of claim 1, wherein the individual is a human or pet animal.
12:
- The method of claim 1, wherein the composition is in a form selected from the group consisting of a nutritional composition, an oral nutritional supplement provided as sole source of nutrition, an oral nutritional supplement provided as a source of partial nutrition, and a pharmaceutical product.
13:
- The method of claim 1, wherein the composition comprises 1 to 20 wt. % of a plant extract or plant concentrate, and the at least one cocoa polyphenol is between 20 and 60 wt. % of the plant extract or plant concentrate.
14:
- The method of claim 1, wherein the composition has a caloric density of 0.5-3.0 kcal/ml.
15:
- The method of claim 1, wherein the composition comprises 10-40 en % protein, 10-60 en % carbohydrates, and 20-80 en % fat.
16:
- The method of claim 15, wherein the fat is selected from the group consisting of fish oil, vegetable oil, medium chain triglycerides which are 8 to 14 carbon atoms long, and mixtures thereof.
17:
- The method of claim 1, wherein the composition comprises carbohydrates selected from the group consisting of maltodextrin, starch, lactose, modified carbohydrates, sugar alcohols, and mixtures thereof.
18:
- The method of claim 1, wherein the at least one fermentable dietary fiber is 25 wt. % to 35 wt. % of the composition.
19:
- The method of claim 1, wherein:
- the at least one fermentable dietary fiber is selected from the group consisting of pectin, hydrolyzed pectin, beta-glucan, inulin, fructo-oligosaccharides, galacto-oligosaccharides, alginic acids, raffinose, xylose, polydextrose, lactulose, Acacia gum, Guar Gum, and milk-derived oligosaccharides;
- and
- the composition comprises 2 to 80% (w/w) of the at least one fermentable dietary fiber.
1 more element
20:
- The method according to claim 1, wherein the at least one fermentable dietary fiber is pectin.