Multi-arm single molecular weight polyethylene glycol active derivative and application thereof

A multi-arm single molecular weight polyethylene glycol active derivative having the following structure:

• AX1—R—X2-PEG-F)n (V)
• wherein A is a core structure, and is a polyol group selected from the group consisting of:
• residues of pentaerythritol, oligo-pentaerythritol, glycerol and oligoglycerol, and glyceryl ether groups thereof,
• X1 is a linking group selected from any one or a combination of two or more of the group consisting of:
• —(CH2)i—, —(CH2)iO—, —(CH2)iNHCO—, —(CH2)iCONH—, —(CH2)iOCO—, and —(CH2)iCOO—, and i is an integer from 1 to 10,
• R is a linking group selected from any one or a combination of two or more of the group consisting of:
• —NHCO—, —CONH—, —OCO—, —COO—, —O—,
• X2 is a linking group selected from any one or a combination of two or more of the group consisting of:
• —(CH2)j—, —(CH2)jO—, —(CH2)jCO—, —(CH2)jNH—, —(CH2)jNHCO—, —(CH2)jCONH—, —(CH2)jOCO— and —(CH2)jCOO—, and j is an integer from 0 to 10,
• PEG has the following structure:
• —(CH2CH2O)m—, m is an integer from 4 to 200, and
• F is the same or different —X3—Z type structure,
• X3 is a linking group selected from any one or a combination of two or more of the group consisting of:
• —(CH2)k—, —(CH2)kO—, —(CH2)kCO—, —(CH2)kNH—, —(CH2)kNHCO—, —(CH2)kCONH—, —(CH2)kNHCONH—, —(CH2)kOCO—, —(CH2)kCOO—, —(CH2)kOCOO— and —(CH2)kOCONH—, and k is an integer from 0 to 10,
• Z is an active terminal group selected from any one of the group consisting of:
• —H, —NH2, —ONH2, —SH, —N3, —Br, —CONH2, —CONH2, —COONH2, —COOH, —PO3H, —CHO, —CO—HA, —C≡CH,
• —COCH═CH2, —COC(CH3)═CH2, —CN, —CH2CH═CH2, —CH═CH—COOH, —N═C═O,
• C1-6 alkyl and C1-6 alkoxy,
• HA is a halogen atom,
• E is C1-10 hydrocarbyl or fluorine-containing C1-10 hydrocarbyl,
• L1-3 are the same or different C1-10 alkyl or C1-6 alkoxy groups,
• n is an integer from 3 to 24.