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US 2023/0093783 A9Published application
Disposable Alternating Tangential Flow Filtration Units
AssigneeRepligen Corporation
InventorsTravis R. Ward, Steven R. Pearl, Adam Malone, Tim Erlandson
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Abstract
Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.
Claims20
A disposable alternating tangential flow housing and diaphragm pump unit comprising:
- a hollow tube of a sterilizable, non-toxic, rigid plastic;
- a first pump hemisphere secured to an end of the hollow tube, wherein the first pump hemisphere comprises a first circumferential flange, and wherein an opening in the first pump hemisphere enables fluid to flow between the first pump hemisphere and the hollow tube;
- a second pump hemisphere comprising a second circumferential flange configured to mate with the first circumferential flange;
- a flexible diaphragm configured to be arranged between the first and second circumferential flanges;
- and
- a clamp ring configured to be placed over one of the first and second pump hemispheres to extend circumferentially and continuously around the first circumferential flange and the second circumferential flange to seal the flexible diaphragm between the first circumferential flange and the second circumferential flange.
3 more elements
A cylindrical disposable alternating tangential flow pump clamp ring comprising:
- a first cylindrical portion comprising a first continuous inner surface configured to be removably disposed over and engaged with a first pump hemisphere;
- and
- a second cylindrical portion comprising a second continuous inner surface configured to be removably disposed over and engaged with a second pump hemisphere to secure the first pump hemisphere and the second pump hemisphere together.
A method of clamping together a disposable alternating tangential flow housing comprising a first pump hemisphere and a second pump hemisphere, the method comprising:
- placing a clamp ring over one of the first and second pump hemispheres to extend circumferentially and continuously around the first pump hemisphere and the second pump hemisphere;
- and
- engaging the inner surface of the clamp ring with the outer surfaces of the first pump hemisphere and the second pump hemisphere to clamp the first pump hemisphere and the second pump hemisphere together.
Dependencies are inferred from the claim text.