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AssigneeAgency for Science, Technology and Research
InventorsYang CHENG, Evan NEWELL
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The present invention relates to peptides and their ability to identify and bind to T cells specific for HBV-infected hepa-tocytes. In an first aspect of the invention, there is provided a peptide comprising an amino sequence selected from the group consisting of STLPETAVVRR, STLPETAVVR, STLPETTVVRR, STLPETTVIRR, STPPETTVVRR, STLPETTVVGR and STIPETTVVRR, wherein the peptide is derived from Hepatitis B virus core169 and is capable of binding HLA-A*1101 and when bound to HLA-A*1101 s capable of identifying T cells specific for Hepatitis B virus. In a second aspect of the invention, there is provided A T cell expressing a T cell receptor (TCR) molecule, wherein the TCR molecule comprises an amino acid sequence selected from the group comprising: CASGDSNSPLHF, CASSGGQIVYEQYF, CSARGGRGGDYTF and CASSQDWTEAFF, the T cell receptor is able to bind to a pep-tide according to the first aspect of the invention.
A peptide comprising an amino sequence selected from the group consisting of STLPETAVVRR (SEQ ID No. 21), STLPETAVVR (SEQ ID No. 22), STLPETTVVRR (SEQ ID No. 23), STLPETTVIRR (SEQ ID No. 24), STPPETTVVRR (SEQ ID No. 25), STLPETTVVGR (SEQ ID No. 26) and STIPETTVVRR (SEQ ID No. 27), wherein the peptide is derived from Hepatitis B virus core169 and is capable of binding HLA-A*1101 and when bound to HLA-A*1101 is capable of identifying T cells specific for Hepatitis B virus.
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Dependencies are inferred from the claim text.