Polymer retention screening method
AssigneeBASF SE
InventorsKristin Gabriele Mohr, Lu Zhang, Leonora Ethleen Leigh, Padma P. Varanasi
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Abstract
The present invention discloses analytical high throughput methods for accurately, reliably, and efficiently screening and identifying polymers that are substantive to a particular material, such as hydroxyapatite. The present invention also discloses liquid chromatography columns for screening and identifying polymers that are substantive to a particular material, methods of preparing such liquid chromatography columns, and kits that may be used to screen and identify polymers that are substantive to a particular material.
Claims23
A method for screening polymers that are substantive to a material, the method comprising:
- running a solution of a test polymer through a liquid chromatography (LC) column comprising the material to determine a retention time profile for the test polymer,
- wherein a longer retention time profile as compared to a baseline is indicative of the test polymer being more substantive to the surface as compared to the baseline.
11-16. (canceled)
A method for screening polymers that are substantive to a hydroxyapatite, the method comprising:
- coating a liquid chromatography (LC) column comprising hydroxyapatite with sterilized saliva;
- and
- running a solution of a test polymer through the LC to determine a retention time profile for the test polymer,
- wherein a longer retention time profile as compared to a baseline is indicative of the test polymer being more substantive to the hydroxyapatite as compared to the baseline.
23-26. (canceled)
A liquid chromatography (LC) column for screening polymers that are substantive to a hydroxyapatite, the LC column comprising a hydroxyapatite LC column coated with sterilized saliva.
(canceled)
Dependencies are inferred from the claim text.