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AssigneeXeris Pharmaceuticals, Inc.
InventorsMartin DONOVAN, Steven PRESTRELSKI, Scott COLEMAN, Brian SLOAT, Diana BOWMAN, Richard FITCH
Estimating the term…
The present invention provides compositions comprising one or more active pharmaceutical ingredients, wherein the compositions are in the form of high solids concentration pastes capable of being injected in relatively low volumes into an animal using standard commercially available syringes. The invention also provides methods of making such compositions, particularly those compositions comprising high molecular weight active ingredients (e.g., antibodies, enzymes and other proteins and peptides) at relatively high therapeutic concentrations in the high solids concentration pastes. The invention further provides methods of using such formulations in treating, preventing and/or ameliorating certain diseases and physical disorders in animals, including humans, in need thereof. The invention also provides kits comprising the formulations of the invention and a suitable syringe, which in some aspects may be pre-loaded or pre-filled with a composition of the invention.
A composition comprising a paste having a solids concentration of greater than about 350 mg/mL, said paste comprising one or more active pharmaceutical ingredients, one or more pharmaceutically acceptable excipients, and one or more non-solvent fluids, wherein said paste is capable of being injected subcutaneously, intracutaneously or intramuscularly into an animal in a volume of 3 ml or less at a flow rate of at least 30 μL/s using a commercially available needle/syringe combination.
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Dependencies are inferred from the claim text.