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US 2023/0082230 A1Published application
Application of epigenetic chromosomal interactions in cancer diagnostics
AssigneeOxford Biodynamics PLC
InventorsFrancis Hector Grand, Aroul Selvam Ramadass, Alexandre Akoulitchev, Ewan Hunter
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Abstract
The invention provides a method of determining the epigenetic chromosome interactions which are relevant to a prognostic companion epigenetic test for cancer.
Claims15
-15. (canceled)
A method for quantitatively detecting a ligated sequence which is relevant to a chromosome interaction using a probe which is detectable upon activation during a PCR reaction,
- wherein said ligated sequence comprises sequences from two chromosome regions that come together in an epigenetic chromosome interaction,
- wherein said method comprises contacting the ligated sequence with the probe during a PCR reaction, and detecting the extent of activation of the probe, and wherein said probe binds the ligation site.
19-21. (canceled)
Dependencies are inferred from the claim text.