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US 2023/0079898 A1Published application
Compositions and methods for treating and preventing hepatitis b and d
AssigneeSvenska Vaccinfabriken Produktion AB
InventorsMatti Sällberg, Lars Frelin
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Abstract
Disclosed herein are immunogenic compositions or product combinations of engineered hepatitis B and hepatitis D nucleic acids, genes, peptides, or proteins that can be used to illicit an immune response against a hepatitis B and/or hepatitis D infection. Also disclosed are methods of using the immunogenic compositions or product combinations in subjects to generate immune responses against HBV and/or HDV by administering the compositions or combinations with a nucleic acid prime and polypeptide boost approach.
Claims2
An immunogenic composition or product combination comprising:
- (a) a nucleic acid comprising at least one nucleic acid sequence encoding hepatitis D antigen (HDAg) and at least one nucleic acid sequence encoding PreS1;
- and
- (b) a polypeptide comprising at least one HDAg polypeptide sequence and at least one PreS1 polypeptide sequence.
2-49. (canceled)
Dependencies are inferred from the claim text.