Compositions and Methods for Enhancing Beta Cell Maturation, Health and Function
AssigneesThe Regents of the University of California, Bar-Il-An University
InventorsSteven Chessler, Arie Lev Gruzman, Jean-Paul Lellouche, Anna Munder
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Abstract
The present invention provides compositions and methods for enhancing beta cell maturation, health and function. The invention may be used for increasing insulin secretion in a cell, promoting the formation of cell clusters, or reducing cell death. In some embodiments, the compositions and methods provide a treatment for diabetes. In some embodiments, the composition comprises an agent which increases a β-cell surface protein expression, activity or both.
Claims23
A composition comprising an agent that increases a β-cell surface protein activity.
(canceled)
(canceled)
A cell engineered to secrete insulin, wherein the cell expresses a recombinant β-cell surface protein or a β-cell protein-derived peptide.
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A method for treating or preventing a condition associated with reduced insulin secretion in a subject in need thereof, the method comprising:
- differentiating a stem cell into a mature β-cell by culturing the stem cell in the presence of a composition comprising an agent that increases a β-cell surface protein activity, thereby producing a cluster of mature β-cells;
- and
- transplanting the cluster of mature β-cells to the subject.
Dependencies are inferred from the claim text.