Bacteriophage compositions and uses thereof
AssigneeYale University
InventorsPaul Turner, Alita Burmeister, Benjamin Chan, Kaitlyn Kortright, John Wertz
Life of this patent
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Abstract
The present invention includes compositions and methods for increasing antibiotic sensitivity and/or decreasing virulence in bacteria.
Claims42
A method of increasing antibiotic sensitivity and/or decreasing virulence in a pathogenic bacteria, the method comprising:
- contacting the bacteria with a lytic bacteriophage selected from the group consisting of OMKO1, LPS-5, TIVP-H6, LPS-TLTL,TIVP-27, SFA1-1, SF60B, SFNHSI, SF37B, PG-I1, and U136B.
A pharmaceutical composition comprising one or more lytic bacteriophages selected from the group consisting of OMKO1, LPS-5, TIVP-H6, LPS-TLTL, TIVP-27, SFA1-1, SF60B, SFNHSI, SF37B, PG-I1, and U136B.
A method of disrupting a pathogenic bacteria associated with a biofilm, the method comprising contacting the bacteria with a lytic bacteriophage selected from the group consisting of OMKO1, LPS-5, TIVP-H6, LPS-TLTL, TIVP-27, SFA1-1, SF60B, SFNHSI, SF37B, PG-I1, and U136B.
A method of preventing formation of a biofilm on a surface, the method comprising contacting the surface with a lytic bacteriophage selected from the group consisting of OMKO1, LPS-5, TIVP-H6, LPS-TLTL, TIVP-27, SFA1-1, SF60B, SFNHSI, SF37B, PG-I1, and U136B.
A composition comprising an LPS-5 bacteriophage targeting Pseudomonas aeruginosa, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 1.
A composition comprising an OMKO1 bacteriophage targeting Pseudomonas aeruginosa, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 2.
A composition comprising a TIVP-H6 bacteriophage targeting Pseudomonas aeruginosa, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 3.
A composition comprising an LPS-TLTL bacteriophage targeting Pseudomonas aeruginosa, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 4.
A composition comprising an TIVP-27 bacteriophage targeting Pseudomonas aeruginosa, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 5.
A composition comprising an SFA1-1 bacteriophage targeting a Shigella spp. bacteria, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 6.
A composition comprising an SF60B bacteriophage targeting a Shigella spp. bacteria, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 7.
A composition comprising an SFNHSI bacteriophage targeting a Shigella spp. bacteria, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 8.
A composition comprising an SF37B bacteriophage targeting a Shigella spp. bacteria, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 9.
A composition comprising a PG-I1 bacteriophage targeting Staphylococcus aureus, the bacteriophage having a genome comprising at least one nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 10-12.
A composition comprising a U136B bacteriophage targeting E. coli, the bacteriophage having a genome comprising a nucleic acid sequence comprising SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.