Loading patent…
AssigneeOptolane Technologies Inc.
InventorsSeung-Shick SHIN, Do young LEE, Seong-Min SEO, Kyung-Hak CHOI, Jae-Chul PYUN
Estimating the term…
The present invention relates to a switching binder binding to an antigen-binding portion of an antibody, a preparation method thereof, and a pharmaceutical composition, an assay kit, and an antigen and antibody assay method, each utilizing the same. A switching binder according to an embodiment of the present invention includes an amino acid sequence selected from framework regions of a heavy chain or a light chain, which constitutes an antigen-binding portion of an antibody, wherein the amino acid sequence includes, in addition to the heavy chain or the light chain, a first antibody-binding portion or a second antibody-binding portion that binds to a framework region of a heavy chain or a light chain, which constitutes the antigen-binding portion, the amino acid sequence being able to bind specifically to the antigen-binding portion of the antibody and then be separated from the framework region when a target antigen is provided.
A switching binder that reversibly binds to at least a portion of a framework region (FR) of an antibody and is separated from the framework region when a target antigen that specifically reacts with the antibody binds to the antibody.
2-3. (canceled)
A switching binder comprising an amino acid sequence selected from a framework region of a heavy chain constituting an antigen-binding portion of an antibody, wherein the amino acid sequence contains a first antibody-binding portion reversibly bound to a framework region of a light chain constituting the antigen-binding portion together with the heavy chain.
A switching binder comprising an amino acid sequence selected from a framework region of a light chain constituting an antigen-binding portion of an antibody,
6-8. (canceled)
12-20. (canceled)
A switching binder comprising:
(canceled)
(canceled)
29-30. (canceled)
35-45. (canceled)
Dependencies are inferred from the claim text.