Macrophage-derived engineered vesicles for targeted delivery and treatment
AssigneeUniversity of Kentucky Research Foundation
InventorsChris Richards, Jill Kolesar
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Abstract
Compositions and methods described in this document make use of macrophage derived engineered vesicles (MEV) having specificity for delivery to a target environment, for use in modifying macrophage phenotype and/or treating a condition. Further disclosed are MEV derived from a specific phenotype encapsulating a therapeutic agent for targeted therapeutic delivery.
Claims20
A method of making a macrophage-derived engineered vesicle (MEV), comprising:
- (a) providing a first macrophage of a first phenotype;
- and
- (b) fragmenting a cell membrane of the first macrophage and allowing the fragmented membrane to assemble into a first phenotype MEV derived from the first macrophage.
A method of modifying a phenotype of a macrophage, comprising:
- (a) providing a macrophage of a second phenotype;
- and
- (b) incubating the macrophage with a macrophage-derived engineered vesicle (MEV) of a first phenotype, thereby shifting the macrophage to a first phenotype.
A composition, comprising a macrophage-derived engineered vesicle (MEV) having a first phenotype, derived from a target environment, and optionally encapsulating cargo.
Dependencies are inferred from the claim text.