Method for preparing fibrosis-encapsulated tumoroid, and use thereof
OwnerBaek Gil Kim, Yeonsue Jang +2inventors
InventorsBaek Gil Kim, Yeonsue Jang, Nam Hoon Cho, Suki Kang
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Abstract
The present invention relates to a method for producing a fibrosis-encapsulated tumoroid (FET), and the use of the fibrosis-encapsulated tumoroid. According to the present invention, an analogue that is close to real solid cancer tissue is produced using induced pluripotent stem cell-derived cell. The analogue has significant improvement over conventional tumoroids, which fail to perfectly reflect the characteristics of human solid cancer and have a very high probability of failure in the clinical validation stage. Thus, the present invention is expected to be widely used in the fields of new anticancer drug development and precision medicine.
Claims21
A method for producing a fibrosis-encapsulated tumoroid, the method comprising steps of
- (a) obtaining cancer cells isolated from a subject;
- and
- (b) co-culturing the cancer cells with induced pluripotent stem cells (iPSCs) or induced pluripotent stem cell-derived cells to form a spheroid-shaped culture.
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Dependencies are inferred from the claim text.