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AssigneeRuprecht-Karls-UniversitäT Heidelberg
InventorsElena CZINK, Christine ENGELAND, Guy UNGERECHTS
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The present invention relates to a recombinant virus of the family Paramyxoviridae comprising an expressible polynucleotide encoding at least one of (i) a tumor antigen, (ii) a fragment of a tumor antigen, and (iii) a variant of (i) or (ii). The present invention further relates to a polynucleotide encoding said recombinant virus of the family Paramyxoviridae and to a host cell comprising said recombinant virus of the family Paramyxoviridae and/or said polynucleotide encoding said recombinant virus of the family Paramyxoviridae. Moreover, the present invention relates to a method for activating immune cells with antitumor activity in a sample comprising cancer cells and to further means, methods, and uses related to the present invention.
1-42. (canceled)
A replication competent recombinant virus of the family Paramyxoviridae comprising an expressible polynucleotide encoding at least one of (a) the tumor antigen L-dopachrome-tautomerase (TRP2), (b) a fragment of the tumor antigen TRP2 comprising at least one antigenic epitope of TRP2, and (c) a variant of (a) or (b), wherein the variant is 90% identical to the sequence of TRP2 depicted in SEQ ID NO:
Dependencies are inferred from the claim text.