New antibacterial compound isolated from psiloxylon mauritianum and its derivatives
AssigneesJonathan Sorres, Centre National de la Recherche Scientifique (CNRS)
InventorsJonathan SORRES, Véronique EPARVIER
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Abstract
Aspidin BB derivatives, compositions containing them, and methods of making and using them.
Claims25
1-24. (canceled)
A method of treating a microbial infection, the method comprising administrating a composition comprising an aspidin BB derivative of formula (I)
- wherein,
- n is from 0 to 16;
- R2 and R3 are selected from the group consisting of hydrogen, OH, Oalkyl, Oaryl, NH2, NHalkyl, NHaryl, N(alkyl)2, N(aryl)2, and alkyl;
- R1 and R4 are selected from the group consisting of, OH, Oalkyl, Oaryl, NH2, NHalkyl, NHaryl, N(alkyl)2, N(aryl)2, alkyl, SH, Salkyl, and SO2H;
- G1 and G2 are selected from the group consisting of OH, Oalkyl, NH2, NHalkyl, NHaryl, N(alkyl)2, N(aryl)2, and SH;
- and
- G3, G4n G5, and G6 are selected from the group consisting of hydrogen, CI, BR, F, I, NO2, CN, NH2, NHalkyl, NHaryl, N(alkyl)2, N(aryl)2, SH, Salkyl, and sulfate,
- to a patient in need thereof.
The method according to claim 21, wherein said gram-negative bacterial strain is chosen from Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.
An antimicrobial composition against Gram-negative bacteria, comprising an aspidin compound of formula (I) in combination with an outer membrane permeabilizer.
An aspidin BB derivative of formula (II)
Dependencies are inferred from the claim text.