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US 2023/0061378 A1Published application
Pertussis toxin binding protein
AssigneeSuzhou Alphamab Co., Ltd.
InventorsTing Xu, Xiaoxiao Wang, Ling Wang, Danming Zhu, Li Gao
Life of this patent
Estimating the term…
Abstract
The invention relates to the field of biomedicine, and an anti-pertussis toxin (PT) single domain antibody and derivative protein thereof are disclosed. Specifically, a pertussis toxin-binding protein and use thereof are disclosed.
Claims21
A pertussis toxin-binding protein capable of specifically binding to pertussis toxin and comprising at least one immunoglobulin single variable domain comprising CDR1, CDR2 and CDR3 selected from the group consisting of:
- (1) CDR1 shown in SEQ ID NO:
- 1, CDR2 shown in SEQ ID NO:
- 2, and CDR3 shown in SEQ ID NO:
- 3;
- (2) CDR1 shown in SEQ ID NO:
- 4, CDR2 shown in SEQ ID NO:
- 5, and CDR3 shown in SEQ ID NO:
- 6;
- (3) CDR1 shown in SEQ ID NO:
- 7, CDR2 shown in SEQ ID NO:
- 8, and CDR3 shown in SEQ ID NO:
- 9;
- (4) CDR1 shown in SEQ ID NO:
- 10, CDR2 shown in SEQ ID NO:
- 11, and CDR3 shown in SEQ ID NO:
- 12;
- (5) CDR1 shown in SEQ ID NO:
- 13, CDR2 shown in SEQ ID NO:
- 14, and CDR3 shown in SEQ ID NO:
- 15;
- (6) CDR1 shown in SEQ ID NO:
- 16, CDR2 shown in SEQ ID NO:
- 17, and CDR3 shown in SEQ ID NO:
- 18;
- (7) CDR1 shown in SEQ ID NO:
- 19, CDR2 shown in SEQ ID NO:
- 20, and CDR3 shown in SEQ ID NO:
- 21;
- (8) CDR1 shown in SEQ ID NO:
- 22, CDR2 shown in SEQ ID NO:
- 23, and CDR3 shown in SEQ ID NO:
- 24;
- (9) CDR1 shown in SEQ ID NO:
- 25, CDR2 shown in SEQ ID NO:
- 26, and CDR3 shown in SEQ ID NO:
- 27;
- (10) CDR1 shown in SEQ ID NO:
- 28, CDR2 shown in SEQ ID NO:
- 29, and CDR3 shown in SEQ ID NO:
- 30;
- (11) CDR1 shown in SEQ ID NO:
- 31, CDR2 shown in SEQ ID NO:
- 32, and CDR3 shown in SEQ ID NO:
- 33;
- (12) CDR1 shown in SEQ ID NO:
- 34, CDR2 shown in SEQ ID NO:
- 35, and CDR3 shown in SEQ ID NO:
- 36;
- (13) CDR1 shown in SEQ ID NO:
- 37, CDR2 shown in SEQ ID NO:
- 38, and CDR3 shown in SEQ ID NO:
- 39.
49 more elements
16-19. (canceled)
Dependencies are inferred from the claim text.