Surface modifying coating for medical devices

A surface lubricant composition comprising:

• a hydrolyzable first organopolysiloxane capable of a crosslinking reaction upon exposure to moisture and having a viscosity of about 150 centistokes;
• a second organopolysiloxane that is copolymerizable with said first organopolysiloxane and has viscosity of equal to or greater than about 5,000 centistokes;
• a solvent to mix the said first and second organopolysiloxanes to form a homogeneous liquid solution, wherein said solvent comprises both xylene and heptane;
• and
• water;
• and
• wherein the composition is free of catalysts, crosslink agents, and additional energy sources to support crosslinking between said hydrolyzable first organopolysiloxane and said second organopolysiloxane.

A surface lubricant composition consisting of:

• a hydrolyzable first organopolysiloxane capable of a crosslinking reaction upon exposure to moisture and having a viscosity of about 150 centistokes;
• a second organopolysiloxane that is copolymerizable with said first organopolysiloxane and has a viscosity of equal to or greater than about 5,000 centistokes;
• a solvent to mix said first organopolysiloxane with said second organopolysiloxane to form a homogeneous liquid solution, wherein said solvent comprises xylene and heptane;
• and
• water.

A syringe comprising:

• a tubular syringe barrel having an interior surface;
• a plunger slidingly mountable within the syringe barrel and having an outwardly directed surface for slidably engaging the interior surface of the syringe barrel;
• the interior surface of the syringe barrel and the plunger defining a container chamber configured to contain a medicament;
• a lubricious coating applied to at least one of the syringe barrel interior surface and the outwardly directed surface of the plunger;
• and
• wherein the lubricious coating is a mixture of at least two silicones comprising a first silicone being a hydrolyzable siloxane capable of a crosslinking reaction upon exposure to moisture at ambient temperature and a second silicone being an organopolysiloxane that is copolymerizable with the first silicone.

A method for delivering a pharmaceutical product comprising:

• providing an injection system comprising:
• a tubular syringe barrel having an interior surface;
• a plunger slidingly mountable within the syringe barrel and having an outwardly directed surface for slidably engaging the interior surface of the syringe barrel;
• the interior surface of the syringe barrel and the plunger defining a chamber containing a medicament;
• and
• a lubricious coating applied to at least one of the syringe barrel interior surface and the outwardly directed surface of the plunger;
• wherein the lubricious coating is a mixture of at least two silicones comprising a first silicone being a hydrolyzable siloxane capable of crosslinking reaction upon exposure to moisture at ambient temperature and a second silicone being an organopolysiloxane that is copolymerizable with the first silicone;
• applying a distally directed force on the plunger in order to deliver the pharmaceutical product from the chamber of the injection system, whereby the distally directed force necessary to break loose and initially move the plunger from an at rest position in the syringe barrel is less than twice a distally directed extrusion force needed to continue movement of the plunger within the syringe barrel once the plunger is moving.

A surface lubricant composition comprising:

• i. a hydrolyzable first organopolysiloxane capable of crosslinking reaction upon exposure to moisture and having a viscosity of less than or equal to 1,000 centistokes;
• wherein said first organopolysiloxane is represented by the following structural formulae (I);
• wherein at least two of R1, R2, R3, R4, R5 and R6, are independently selected from the group consisting of acetoxy, enoxy, oxime, and (C1-C6)alkoxy groups;
• wherein the remaining of R1, R2, R3, R4, R5 and R6 that are not defined above, are independently selected from the group consisting of (C1-C6)alkyl and —NRR′, wherein R and R′ are independently H, (C1-C6)alkyl, aryl, or halo(C1-C6)alkyl;
• wherein R7 and R8 are independently selected from the group consisting of (C1-C6)alkyl, halo (C1-C6)alkyl, aryl, haloaryl, (C3-C7)cycloalkyl, (C1-C6)aralkyl, fluoro, and fluoro(C1-C6)alkyl;
• wherein m is about 5 to about 1000;
• and
• wherein said first organopolysiloxane is optionally a copolymer comprising different organopolysiloxanes of formulae I;
• and
• ii. a second organopolysiloxane that is copolymerizable with said first organopolysiloxane and has viscosity of greater than or equal to 5,000 centistokes;
• wherein said second organopolysiloxane is represented by the following structural formulae (II)
• wherein Ra, Rb, Rc, Rd, Re, and Rf are independently selected from the group consisting of (C1-C6)alkyl, halo(C1-C6)alkyl, aryl, haloaryl, (C3-C7)cycloalkyl, (C1-C6)aralkyl, fluoro, and fluoro(C1-C6)alkyl;
• wherein n is about 200 to about 2000, more preferably about 600 to about 1000;
• and
• wherein said second organopolysiloxane is optionally a copolymer comprising different organopolysiloxanes of formulae II.