# US 2023/0058905 A1 · Assembly comprising an oct device for ascertaining a 3d reconstruction of an object region volume, computer program, and computer-implemented method for same

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- Number: US 2023/0058905 A1
- Document ID: US20230058905A1
- Status: Published application
- Kind: A1
- Application number: 17/793,791
- Filed: 2021-01-25
- Published: 2023-02-23
- Earliest claimed: 2020-01-28
- Assignees: Carl Zeiss Meditec AG
- Applicants: Carl Zeiss Meditec AG
- Inventors: Holger MATZ; Christian VOIGT; Christoph HAUGER; Delbert Peter ANDREWS; Nancy HECKER-DENSCHLAG
- Web page: https://patentgrep.com/patent/US20230058905A1

## CPC

- A61B 34/20: Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B 3/102: {for optical coherence tomography [OCT]}
- A61B 3/1225: {using coherent radiation}
- A61B 3/1233: {for measuring blood flow, e.g. at the retina}
- A61B 3/1241: {specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography}
- A61B 3/13: Ophthalmic microscopes
- A61B 34/10: Computer-aided planning, simulation or modelling of surgical operations
- A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers}
- A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts}
- A61F 9/007: Methods or devices for eye surgery
- G06T 7/11: Region-based segmentation
- G06T 7/30: Determination of transform parameters for the alignment of images, i.e. image registration
- G06T 12/00: Tomographic reconstruction from projections
- A61B 2034/107: {Visualisation of planned trajectories or target regions}
- A61B 2034/2065: {Tracking using image or pattern recognition}
- A61B 2090/3937: {Visible markers}
- G06T 2207/10101: Optical tomography; Optical coherence tomography [OCT]
- G06T 2207/30041: Eye; Retina; Ophthalmic
- G06T 2207/30204: Marker
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL

## Abstract

The invention relates to an assembly (10) comprising an OCT device (20) for scanning an object region volume (22) arranged in an object region (18) using an OCT scanning beam (21), an object (24) with a section, which can be arranged in the object region (18) and which can be located in the object region volume (22) by means of the OCT device (20), in the object region volume (22), and a calculating unit (60) which is connected to the OCT device (20) and contains a computer program for ascertaining a 3D reconstruction of the object region volume (22) and for ascertaining the position of the section of the object (24) in the object region volume (22) by processing OCT scanning information obtained by scanning the object region volume (22) using the OCT device (20). According to the invention, the computer program has a calculation routine for ascertaining a target area (90) in the 3D reconstruction of the object region volume (22), said calculation routine determining a reference variable for the object (24) relative to the target area (90). The object (24) is designed as a surgical instrument which has a capillary with an opening for discharging a medium. The calculation routine of the computer program is used to ascertain an actual value of the volume of the medium discharged through the opening of the capillary in the target area by comparing data of the target area in the 3D reconstruction of the object region volume (22) and/or by comparing scanning information of the target area obtained by scanning the object region volume (22) using the OCT device (20) prior to and while discharging the medium. The invention also relates to a computer program and to a method for determining the volume of a medium discharged in an object region (18) through an opening by means of a surgical instrument with a capillary.

## Claims

### Claim 1

An arrangement comprising:
an OCT device for scanning an object region volume in an object region by means of an OCT scanning beam;
an item which has a section that is arrangeable in the object region volume and is localizable there by means of the OCT device; and
a computer unit which is connected to the OCT device and which contains a computer program for determining a 3-D reconstruction of the object region volume and determining the relative position of the section of the item in the object region volume by processing OCT scanning information obtained by means of the OCT device by scanning the object region volume,
wherein the computer program has a computing routine for determining a target area in the 3-D reconstruction of the object region volume, said computing routine determining a guide variable for the item in relation to the target area, the item being in the form of a surgical instrument which has a capillary with an opening for the release of a medium and the computing routine of the computer program serving to determine an actual value of the volume of the medium released into the target area through the opening of the capillary by comparing data of the target area in the 3-D reconstruction of the object region volume and/or by comparing scanning information of the target area obtained by means of the OCT device by scanning the object region volume before and during the release of the medium.

### Claim 2 (depends on 1)

The arrangement as claimed in claim 1, wherein the computer program is configured to determine a 3-D reconstruction of the object region volume from data which are obtained by examining the object region volume using an imaging method by scanning the object region volume by means of the OCT scanning beam of the OCT device, and/or which are data determined presurgery and/or which are data relating to sensor signals for determining a position of the section of the item in the object region volume.

### Claim 3 (depends on 1)

The arrangement as claimed in claim 1, wherein the computer program is designed to determine the relative spatial position of data in relation to one another by means of a registration method, said data comprising data from the following group: scanning information obtained by means of the OCT device by scanning the object region volume, the object region volume, data from further imaging methods, in particular optical image representations, Mill data, CT data, ultrasound images, endoscopy images, a position of the section of the item, data determined presurgery, position sensor signals.

### Claim 4 (depends on 1)

The arrangement as claimed in claim 1, wherein:
the OCT device is designed for successive continuous scanning of the object region volume by means of the OCT scanning beam and/or in that the OCT device is designed for successive continuous scanning of a region of the object region volume containing the section of the item by means of the OCT scanning beam;
and/or
the computer program is designed for successive continuous determination of the 3-D reconstruction of the object region volume and/or for successive continuous determination of the relative position of the section of the item in the object region volume;
and/or
the computer program is designed to determine a spatial target position for the item in the 3-D reconstruction of the object region volume;
and/or
the computer unit is connected to a memory for the provision during surgery of data determined presurgery;
and/or
the computer program is designed to determine target areas and/or spatial target positions in data determined presurgery and/or target areas and/or spatial target positions in the 3-D reconstruction of the object region volume by virtue of the application of methods for segmenting tissue structures and/or tissue layers;
and/or
in that the computer program contains a routine for generating a guide variable in the form of control signals for the item;
and/or
in that the computer program is designed to determine as a guide variable a spatial target position in the target area in the 3-D reconstruction of the object region volume taking account of characteristic features of the item and/or of a further item and/or of the target area in the 3-D reconstruction of the object region volume, and/or taking account of geometric relationships, in particular offset information, between these;
and/or
in that the arrangement comprises a device for visualizing the relative position of the section of the item in the 3-D reconstruction of the object region volume and/or for visualizing data determined presurgery and/or for visualizing the guide variable determined in relation to the target area and/or for visualizing variables derived from the guide variable;
and/or
in that the computer program generates acoustic, optical or haptic indication signals for the surgeon on the basis of the guide variable determined in relation to the target area and/or variables derived therefrom;
and/or
in that the computer program contains a shadowing routine for determining a corrected 3-D reconstruction of the object region volume, said shadowing routine recognizing regions that are shadowed by the item and specifying a compensation rule for the 3-D reconstruction of the object region volume in relation to these regions;
and/or
in that a marker that is localizable by the OCT scanning beam is arranged in the section of the item and/or in the object region;
and/or
in that the computer program contains a scanning routine for scanning the object region volume and/or the section of the item using specific scanning patterns and/or for adjusting a scanning rate, which scans the object region volume at a lower rate in comparison with the position of the section of the item;
and/or
in that the computer program is designed for adjusting the determination rule for the 3-D reconstruction and/or the determination rule for the relative position of the section of the item in the object region volume on the basis of a criterion.

### Claim 5 (depends on 1)

The arrangement as claimed in claim 1, wherein OCT angiography data of the object region volume are generated from the scanning information obtained by means of the OCT device by scanning the object region volume.

### Claim 6 (depends on 5)

The arrangement as claimed in claim 5, wherein the computer program is designed to determine the position and/or dimensions of blood vessels in the target area on the basis of the OCT angiography data, the computing routine of the computer program for determining the target area in the 3-D reconstruction of the object region volume taking account of the course and/or the position and/or the dimensions of the blood vessels in the target area.

### Claim 7 (depends on 1)

The arrangement as claimed in claim 1, wherein the computer program contains a path planning routine which, on the basis of a criterion, calculates an optimal path of the item to the spatial target position.

### Claim 8 (depends on 7)

The arrangement as claimed in claim 7, wherein the criterion is a measure of shadowing that quantifies the presence of shadows caused by the item in the calculated 3-D reconstruction.

### Claim 9 (depends on 1)

The arrangement as claimed in claim 1, wherein the computer program contains a routine for determining a target area and/or a target position for the item in provided data determined presurgery and has a registration routine for registering the data determined presurgery with the 3-D reconstruction of the object region volume and a transfer routine for transferring the target area and/or the target position in the data determined presurgery to the 3-D reconstruction of the object region volume.

### Claim 10 (depends on 1)

The arrangement as claimed in claim 1, wherein the computing routine of the computer program serves to determine as a guide variable a target value for the volume of the released medium by processing the target area in the 3-D reconstruction of the object region volume and/or by processing data determined presurgery and/or by processing OCT scanning information obtained by means of the OCT device by scanning the object region volume and/or by way of an input of a target value by a surgeon.

### Claim 11 (depends on 1)

The arrangement as claimed in claim 1, wherein the computing routine of the computer program is designed to determine as a guide variable for a readjustment of the volume of the released medium a difference between a target value and an actual value of the volume of the medium released into the target area.

### Claim 12 (depends on 1)

The arrangement as claimed in claim 1, wherein the computing routine of the computer program serves to determine as a guide variable the position of a substance to be removed and/or an amount of substance to be removed by processing the target area in the 3-D reconstruction of the object region volume and/or by processing data determined presurgery and/or by way of the input of a target value by a surgeon.

### Claim 13 (depends on 12)

The arrangement as claimed in claim 12, wherein a visualization routine for visualizing the position of the substance to be removed and/or the amount of substance to be removed in the object region volume.

### Claim 14

A computer program for determining a 3-D reconstruction of an object region volume in an object region and for determining the relative position of a section of an item in the object region volume by processing OCT scanning information obtained by means of an OCT device by scanning the object region volume, wherein
a computing routine for determining a target area in the 3-D reconstruction of the object region volume and a guide variable for the item in relation to the target area,
the item being in the form of a surgical instrument which has a capillary with an opening for the release of a medium and
the computing routine serving to determine an actual value of the volume of the medium released into the target area by comparing data of the target area in the 3-D reconstruction of the object region volume and/or scanning information of the target area obtained by means of the OCT device by scanning the object region volume before and during the release of the medium.

### Claim 15

A method comprising
scanning, with an OCT device, an object region volume in an object region by means of an OCT scanning beam;
providing an item, the item being in the form of a surgical instrument which has a capillary with an opening for the release of a medium and which has a section that is arrangeable in the object region volume and is localizable there by means of the OCT device;
determining, by a computer unit which is connected to the OCT device and which contains a computer program, a 3-D reconstruction of the object region volume;
determining a relative position of the section of the item in the object region volume by processing OCT scanning information obtained by means of the OCT device by scanning the object region volume;
determining, by the computer unit, a target area in the 3-D reconstruction of the object region volume;
determining, by the computer unit, a guide variable for the item in relation to the target area; and
determine, by the computer unit, an actual value of the volume of the medium released into the target area through the opening of the capillary by comparing data of the target area in the 3-D reconstruction of the object region volume and/or by comparing scanning information of the target area obtained by means of the OCT device by scanning the object region volume before and during the release of the medium.