USE OF H3K9me3 MODULATION FOR ENHANCING COGNITIVE FUNCTION

A method of prevention or alleviation of a cognitive dysfunction in a subject in need thereof, the method comprising administering a therapeutically effective amount of an SUV39H1 inhibitor compound having the structure of Formula (I):

• wherein, p is 2, 3 or 4;
• and
• R1, R2, R3, R4, R5, R6, R16, and R18 are independently hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —Cl3, —CN, —CHO, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl.