Methods of treating neurological disorders
AssigneeEnClear Therapies, Inc.
InventorsManuel A. Navia, Kasper Roet, Jonathan Fleming
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Abstract
Disclosed is a method for treating a subject having a neurological disorder characterized by the presence of dipeptide repeat proteins comprising contacting the cerebrospinal fluid (CSF) of the subject with an agent capable of removing or degrading the toxic protein.
Claims30
A method of treating a neurological disorder characterized by the presence of a dipeptide repeat protein in cerebrospinal fluid (CSF), the method comprising contacting the CSF of a subject in need thereof with an effective amount of a protease capable of removing or degrading the dipeptide repeat protein, wherein the dipeptide repeat protein comprises two or more repeats of a dipeptide amino acid sequence.
A device comprising:
- a housing forming an interior;
- and
- a protease within the interior;
- the protease being in an effective amount capable of removing or degrading a dipeptide repeat protein in cerebrospinal fluid (“CSF”) of a subject in need thereof, wherein the dipeptide repeat protein comprises two or more repeats of a dipeptide amino acid sequence.
A system comprising:
- a substrate;
- and
- a protease immobilized with the substrate, the protease configured to removing or degrading a dipeptide repeat protein in cerebrospinal fluid (“CSF”) of a subject in need thereof, wherein the dipeptide repeat protein comprises two or more repeats of a dipeptide amino acid sequence.
A composition comprising a protease immobilized with a solid substrate, the protease being capable of degrading or removing a dipeptide repeat protein in cerebrospinal fluid (CSF) of a subject having a neurological disorder, wherein the dipeptide repeat protein comprises two or more repeats of a dipeptide amino acid sequence.
Dependencies are inferred from the claim text.