# US 2023/0054792 A1 · Methods and compositions for the treatment of snake bite

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- Number: US 2023/0054792 A1
- Document ID: US20230054792A1
- Status: Published application
- Kind: A1
- Application number: 17/744,502
- Filed: 2022-05-13
- Published: 2023-02-23
- Earliest claimed: 2021-05-14
- Assignees: Liverpool School of Tropical Medicine; Stichting VU
- Applicants: Liverpool School of Tropical Medicine; Stichting VU
- Inventors: Nicholas Casewell; Laura-Oana Albulescu; Jeroen Kool
- Web page: https://patentgrep.com/patent/US20230054792A1

## CPC

- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 31/10: Sulfides; Sulfoxides; Sulfones
- A61K 31/16: Amides, e.g. hydroxamic acids
- A61P 39/02: Antidotes
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The disclosure herein are materials and methods for the treatment of snake bite. Aspects of the disclosure includes pharmaceutical compositions, and kits, both of which may be of use in the treatment of snake bite.

## Claims

### Claim 1

A method of treating snake bite, the method comprising administering to a subject in need of such treatment a combination comprising varespladib and a metalloproteinase inhibitor selected from the group consisting of: marimastat and DMPS, in therapeutically effective amounts.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the subject is administered a combination of varespladib and marimastat.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the varespladib and marimastat are provided in the same composition or in separate compositions.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the subject is administered a combination of varespladib and DMPS.

### Claim 5 (depends on 5)

The method according to claim 5, wherein the varespladib and DMPS are provided in the same composition or in separate compositions.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the subject is administered a combination of varespladib, marimastat, and DMPS.

### Claim 7 (depends on 8)

The method according to claim 8, wherein the varespladib, marimastat, and DMPS are provided in the same composition or in separate compositions.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the varespladib and the metalloproteinase inhibitor are administered orally, topically and/or by injection.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the varespladib and metalloproteinase inhibitor are administered sequentially.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the snake bite is from a snake native to North America.

### Claim 11 (depends on 10)

The method according to claim 10, wherein the snake bite is from a snake of a genus selected from the group consisting of: Crotalus, Sistrurus, Agkistrodon, Micrurus and Micruroides.

### Claim 12 (depends on 11)

The method according to claim 11, wherein the snake bite is from a snake selected from the group consisting of: Crotalus atrox, Crotalus adamanteus, Crotalus cerastes, Crotalus enyo, Crotalus horridus, Crotalus lepidus, Crotalus mitchellii, Crotalus molossus, Crotalus pricei, Crotalus ruber, Crotalus scutulatus, Crotalus tigris, Crotalus viridis, Crotalus willardi, Sistrurus militaries and Agkistrodon contortrix.

### Claim 13 (depends on 11)

The method according to claim 11, wherein the snake bite is from a snake selected from the group consisting of: Crotalus atrox, Crotalus scutulatus, Crotalus adamanteus, Crotalus horridus, Sistrurus miliarius and Agkistrodon contortrix.

### Claim 14

A pharmaceutical composition comprising a therapeutically effective amount of a combination of varespladib and one or both metalloproteinase inhibitors: marimastat and DMPS, and a pharmaceutically acceptable carrier.

### Claim 15 (depends on 14)

The pharmaceutical composition according to claim 14, which is adapted for administration orally, topically or by injection.

### Claim 16

A kit for treating snake bite, the kit comprising a therapeutically effective amount of a varespladib and one or both metalloproteinase inhibitors: marimastat and DMPS.

### Claim 17 (depends on 16)

A kit according to claim 16, wherein the varespladib and the metalloproteinase inhibitor(s) are in separate compositions.

### Claim 18 (depends on 16)

The kit according to claim 16, wherein the varespladib and the metalloproteinase inhibitor(s) are in the same composition.

### Claim 19 (depends on 16)

The kit according to claim 16, wherein the varespladib and the metalloproteinase inhibitor(s) are formulated for oral, topical and/or injection administration.