# US 2023/0054776 A1 · System and Methods For Sealing a Channel In Tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2023/0054776 A1 - Document ID: US20230054776A1 - Status: Published application - Kind: A1 - Application number: 17/809,187 - Filed: 2022-06-27 - Published: 2023-02-23 - Earliest claimed: 2018-01-10 - Assignees: The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin - Applicants: The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin - Inventors: Garrett Ryan; Colm McGarvey - Web page: https://patentgrep.com/patent/US20230054776A1 ## CPC - A61B 17/00491: {Surgical glue applicators} - A61B 17/0057: {Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009)} - A61B 17/3417: {Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating (syringe needles A61M5/32; dilators A61M29/00)} - A61B 17/3421: {Cannulas} - A61L 24/001: {Use of materials characterised by their function or physical properties} - A61L 24/0031: {Hydrogels or hydrocolloids} - A61L 24/0042: {Materials resorbable by the body} - A61L 24/0094: {containing macromolecular fillers} - A61L 24/043: {Mixtures of macromolecular materials} - A61L 31/129: {containing macromolecular fillers} - A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} - A61L 31/145: {Hydrogels or hydrocolloids} - A61L 31/148: {Materials at least partially resorbable by the body} - A61M 5/178: Syringes - A61M 5/46: having means for controlling depth of insertion - C08L 5/08: Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof - C08L 89/06: derived from leather or skin {, e.g. gelatin} - A61B 2017/00809: {Lung operations} - A61B 2090/062: {penetration depth} - A61B 2090/3966: {Radiopaque markers visible in an X-ray image} - A61L 2400/06: Flowable or injectable implant compositions - A61L 2430/36: for embolization or occlusion, e.g. vaso-occlusive compositions or devices - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06) ## Abstract A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G′) of at least 600 Pa, and a tan δ (G"/G′) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula. ## Claims ### Claim 1 (canceled) ### Claim 2 (canceled) ### Claim 3 (canceled) ### Claim 4 (canceled) ### Claim 5 (canceled) ### Claim 6 (canceled) ### Claim 7 (canceled) ### Claim 8 (canceled) ### Claim 9 (canceled) ### Claim 10 (canceled) ### Claim 11 (canceled) ### Claim 12 (canceled) ### Claim 13 (canceled) ### Claim 14 (canceled) ### Claim 15 (canceled) ### Claim 16 (canceled) ### Claim 17 (canceled) ### Claim 18 (canceled) ### Claim 19 (canceled) ### Claim 20 (canceled) ### Claim 21 A method comprising: injecting a viscoelastic hydrogel using a hydrogel delivery needle into a lung of a patient, the injecting performed at a location adjacent to a visceral pleura of the lung to form an annular sealing plug that embraces the hydrogel delivery needle, the annular sealing plug disposed wholly within the lung and close to or abutting the visceral pleura. ### Claim 22 (depends on 21) The method of claim 21, wherein the annular sealing plug is disposed 0.2 to 6.0 mm distal of the visceral pleura. ### Claim 23 (depends on 21) The method of claim 21, wherein the viscoelastic hydrogel is a shear thinning hydrogel. ### Claim 24 (depends on 21) The method of claim 21, wherein the injection step comprises injection of a volume of 100 to 3000 µl of the viscoelastic hydrogel into the lung to form the annual sealing plug. ### Claim 25 (depends on 21) The method of claim 21, wherein the injection step comprises injection of a volume of 100 to 1000 µl of the viscoelastic hydrogel into the lung to form the annual sealing plug. ### Claim 26 (depends on 21) The method of claim 21, wherein the injection step comprises injection of a volume of 200 to 500 µl of the viscoelastic hydrogel into the lung to form the annual sealing plug. ### Claim 27 (depends on 21) The method of claim 21, wherein the injecting includes injecting the viscoelastic hydrogel into the lung through a hydrogel outlet disposed at a distal-most tip of the hydrogel delivery needle. ### Claim 28 (depends on 21) The method of claim 21, further comprising advancing a coaxial cannula along the hydrogel delivery needle and through the annual sealing plug whereby the annular sealing plug forms an airtight seal against the coaxial cannula. ### Claim 29 (depends on 21) The method of claim 21, further comprising: advancing a coaxial cannula along the hydrogel delivery needle and through the annual sealing plug whereby the annular sealing plug forms an airtight seal against the coaxial cannula; and advancing a lung procedure needle through the coaxial cannula. ### Claim 30 (depends on 21) The method of claim 21, further comprising: advancing a coaxial cannula along the hydrogel delivery needle and through the annual sealing plug whereby the annular sealing plug forms an airtight seal against the coaxial cannula; and advancing a lung biopsy needle through the coaxial cannula. ### Claim 31 (depends on 21) The method of claim 21, further comprising: advancing a coaxial cannula along the hydrogel delivery needle and through the annual sealing plug whereby the annular sealing plug forms an airtight seal against the coaxial cannula; advancing a lung biopsy needle through the coaxial cannula; and taking a biopsy of lung tissue using the lung biopsy needle. ### Claim 32 (depends on 21) The method of claim 21, further comprising: advancing a coaxial cannula along the hydrogel delivery needle and through the annual sealing plug whereby the annular sealing plug forms an airtight seal against the coaxial cannula; and advancing a tissue stain delivery needle through the coaxial cannula. ### Claim 33 (depends on 21) The method of claim 21, further comprising: advancing a coaxial cannula along the hydrogel delivery needle and through the annular sealing plug; removing the hydrogel delivery needle through the cannula; advancing a lung procedure needle through the cannula to a target location within the lung; actuating the lung procedure needle; withdrawing the lung procedure needle through the cannula; and withdrawing the cannula, whereby the annular sealing plug seals the visceral pleura preventing pneumothorax. ### Claim 34 (depends on 33) The method of claim 33, wherein the lung procedure needle is selected from a group including a lung biopsy needle and a tissue stain delivery needle. ### Claim 35 (depends on 21) The method of claim 21, further comprising imaging the lung to correctly position the hydrogel delivery needle to deliver the viscoelastic hydrogel just distal of the visceral pleura. ### Claim 36 (depends on 21) The method of claim 21, wherein the viscoelastic hydrogel is a lung tissue apposing hydrogel having properties that limits its infiltration of lung tissue.