# US 2023/0053880 A1 · Optimization apparatus, optimization method, and program

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- Number: US 2023/0053880 A1
- Document ID: US20230053880A1
- Status: Published application
- Kind: A1
- Application number: 17/790,725
- Filed: 2020-01-10
- Published: 2023-02-23
- Earliest claimed: 2020-01-10
- Assignees: Nippon Telegraph and Telephone Corporation
- Applicants: Nippon Telegraph and Telephone Corporation
- Inventors: Takashi ISEZAKI; Mana SASAGAWA; Yoshiki NISHIKAWA
- Web page: https://patentgrep.com/patent/US20230053880A1

## CPC

- G16H 50/50: for simulation or modelling of medical disorders
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

A technology for simulating physiological activity more appropriately is provided. An optimization apparatus according to an embodiment includes an estimation unit, a first calculation unit, a second calculation unit, and an updating unit. The estimation unit estimates a physiological parameter indicating a physiological state using an estimation model. The first calculation unit calculates a first difference value based on a first estimated value of the physiological parameter in a first time interval and an actually measured value of the physiological parameter in the first time interval. The second calculation unit calculates a second difference value based on the first estimated value and a second estimated value of the physiological parameter in a second time interval previous to the first time interval. The updating unit adjusts the estimation model based on the first difference value and the second difference value.

## Claims

### Claim 1

An optimization apparatus comprising:
a processor; and
a storage medium having computer program instructions stored thereon, when executed by the processor, perform to:
estimate a physiological parameter indicating a physiological state using an estimation model;
to calculate a first difference value based on a first estimated value of the physiological parameter in a first time interval and an actually measured value of the physiological parameter in the first time interval;
calculate a second difference value based on the first estimated value and a second estimated value of the physiological parameter in a second time interval previous to the first time interval; and
adjust the estimation model based on the first difference value and the second difference value.

### Claim 2 (depends on 1)

The optimization apparatus according to claim 1, wherein the computer program instructions further perform to adjusts the estimation model by re-calculating a model parameter of the estimation model such that a sum of the first difference value and the second difference value is minimized.

### Claim 3 (depends on 2)

The optimization apparatus according to claim 2, wherein the computer program instructions further perform to
estimates, as the physiological parameter, a parameter related to intake or discharge of a substance in an organ, and
re-calculates, as the model parameter, a parameter related to a change in a concentration of the substance or a volume of the substance in the organ.

### Claim 4 (depends on 3)

The optimization apparatus according to claim 3, wherein the computer program instructions further perform to acquire action information indicating a detail of an action of a subject and calculate an intake volume or a discharge volume of the substance of the subject based on the action information.

### Claim 5 (depends on 1)

The optimization apparatus according to claim 1, wherein the computer program instructions further perform to calculates the first difference value as a total sum of absolute differences between an average value, a maximum value, and a minimum value of the physiological parameter estimated for the first time interval and an average value, a maximum value, and a minimum value of the physiological parameter actually measured for the first time interval.

### Claim 6 (depends on 1)

The optimization apparatus according to claim 1, wherein the computer program instructions further perform to calculates the second difference value as a total sum of absolute differences between an average value, a maximum value, and a minimum value of the physiological parameter estimated for the first time interval and an average value, a maximum value, and a minimum value of the physiological parameter estimated for the second time interval.

### Claim 7

An optimization method performed by a computer, the method comprising:
estimating a physiological parameter indicating a physiological state using an estimation model;
calculating a first difference value based on a first estimated value of the physiological parameter in a first time interval and an actually measured value of the physiological parameter in the first time interval;
calculating a second difference value based on the first estimated value and a second estimated value of the physiological parameter in a second time interval previous to the first time interval; and
adjusting the estimation model based on the first difference value and the second difference value.

### Claim 8 (depends on 1)

A non-transitory computer-readable medium having computer-executable instructions that, upon execution of the instructions by a processor of a computer, cause the computer to function as the optimization apparatus according to claim 1.