# US 2023/0053587 A1 · A microneedle and a fluid channel system for collecting fluid > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2023/0053587 A1 - Document ID: US20230053587A1 - Status: Published application - Kind: A1 - Application number: 17/797,377 - Filed: 2021-02-10 - Published: 2023-02-23 - Earliest claimed: 2020-02-11 - Assignees: Ascilion AB - Applicants: Ascilion AB - Inventors: Markus Renlund; Pelle Rangsten; Mikael Hillmering - Web page: https://patentgrep.com/patent/US20230053587A1 ## CPC - A61B 5/150022: {for capillary blood or interstitial fluid} - A61B 10/0233: {Pointed or sharp biopsy instruments} - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors} - A61B 5/150419: {comprising means for capillary action} - A61B 5/150984: {Microneedles or microblades} - A61B 5/685: {Microneedles} - A61B 10/0045: {Devices for taking samples of body liquids} - G03F 7/0035: {Multiple processes, e.g. applying a further resist layer on an already in a previously step, processed pattern or textured surface} - A61B 10/0283: {with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe (A61B10/025, A61B10/0266 take precedence)} - A61B 2010/008: {Interstitial fluid} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G03F: PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR; (phototypographic composing devices B41B; photosensitive materials or processes for photographic purposes G03C; electrophotography, sensitive layers or processes therefor G03G) ## Abstract Microneedle (100, 200, 300, 720) comprising an elongated body (110, 210, 310) extending along a longitudinal axis from a top end to a bottom end on a substrate (300, 710), where the elongated body comprises an upper portion (120, 220, 320) and a lower portion (130, 230, 330). The lower portion (130, 230, 330) comprises an internal capillary bore hole (260, 730) extending into the substrate (300, 710). The upper portion (120, 220, 320) of the elongated body (110, 210, 310) has a semi-enclosed internal void space (140, 240) formed by at least three body sides whereof two body sides join at a sharp edge and a third body side is provided with an opening slit (150, 250, 350) extending from the lower portion (130, 230, 330) of the elongated body (110, 210, 310) to the upper end of the third body side. The top end of the elongated body (110, 210, 310) is configured as a bevel to create a sharp tip at the top of said edge, said bevel extending to the third body side. The semi-enclosed internal void space (140, 240) of the upper portion opening to the internal capillary bore hole of the bottom end of the elongated body (110, 210, 310), and the bottom end of the elongated body is connected to the substrate (300, 710). ## Claims ### Claim 1 A microneedle provided on a substrate, comprising: an elongated body extending along a longitudinal axis from a top end to a bottom end on the substrate, wherein: the elongated body comprises an upper portion and a lower portion; the lower portion of the elongated body comprises an internal capillary bore hole extending into the substrate; the upper portion of the elongated body has a semi-enclosed internal void space formed by at least three body sides whereof two body sides join at a sharp edge and a third body side is provided with an opening slit extending from the lower portion of the elongated body to the upper end of the third body side; the top end of the elongated body is configured as a bevel to create a sharp tip at the top of said edge, said bevel extending to the third body side; the semi-enclosed internal void space of the upper portion of the elongated body opening to the internal capillary bore hole of the bottom end of the elongated body; and the bottom end of the elongated body is connected to the substrate. ### Claim 2 (depends on 1) A microneedle according to claim 1, wherein the opening slit is positioned at the centre of a flat body side. ### Claim 3 (depends on 1) A microneedle according to claim 1, wherein at least one surface extending from the semi-enclosed internal void space to the third body side is curved. ### Claim 4 (depends on 3) A microneedle according to claim 3, wherein at least a part of all surfaces extending from the semi-enclosed internal void space to the third body side are curved. ### Claim 5 (depends on 1) A microneedle according to claim 1, wherein the elongated body comprises three body sides. ### Claim 6 (depends on 5) A microneedle according to claim 5, wherein the two body sides joined at a sharp edge are joined to a third body side through curved surfaces. ### Claim 7 (depends on 1) A microneedle according to claim 1, further comprising ridges that extends on an outer surface of the microneedle, where the ridges extends in a direction that is perpendicular to the longitudinal axis. ### Claim 8 (depends on 1) A microneedle according to claim 1, wherein the upper portion is having a first cross-sectional area, and the lower portion is having a second cross-sectional area, wherein the second cross-sectional area is larger than the first cross sectional area. ### Claim 9 (depends on 1) A microneedle according to claim 1, further comprising a dividing plane dividing the upper portion and the lower portion, wherein at least a part of the dividing plane is not in parallel with the substrate plane. ### Claim 10 (depends on 9) A microneedle according to claim 9, wherein the dividing plane between the upper portion and the lower portion is parallel with the bevel. ### Claim 11 (depends on 1) A microneedle according to claim 1, further comprising a curved portion connecting the elongated portion with the substrate. ### Claim 12 A fluid channel system for transporting fluid from a plurality of inlets to a fluid collection area via a fluid channel, the fluid channel system comprising the fluid collection area and at least one sector, wherein each sector comprises a first section and a second section, wherein in each sector the first section comprises at least two inlet channels each connecting an inlet and the second section, wherein in each sector the second section connects the at least two inlet channels of the first section and the fluid collection area via a connective channel, wherein in each sector the at least two inlet channels merge into the connective channel; wherein each sector comprises at least one first droplet formation structure between the at least two inlets channels, wherein the at least one first droplet formation structure is arranged to collect fluid by reducing the fluid interface area to air and enlarge the fluid interface area to the channel wall via channel wall geometry, moving from one inlet channel towards another inlet channel than the one inlet channel; each connective channel comprises a second droplet formation structure, wherein the second droplet formation structure is arranged at the end of the connective channel providing an outlet to the fluid collection area and the second droplet formation structure is arranged to collect fluid moving from at least one connective channel; and wherein the fluid channel is defined at least by the at least two inlet channels and the at least one connective channel. ### Claim 13 (depends on 12) A fluid channel system according to claim 12, wherein the at least one first droplet formation structure is arranged to release collected fluid towards the connective channel. ### Claim 14 (depends on 12) A fluid channel system according to claim 12, comprising at least two sectors. ### Claim 15 (depends on 12) A fluid channel system according to claim 12, wherein each first section connects at least three inlets to the fluid collection area via the connective channel. ### Claim 16 (depends on 12) A fluid channel system according to claim 12, wherein each first droplet formation structure between each two inlet channels comprises two adjacent curved walls joined at an angle of less than 180°, such as less than 120°, 90°, 45°, 30°, 15° or 10°. ### Claim 17 (depends on 12) A fluid channel system according to claim 12, wherein each second droplet formation structure comprises two adjacent curved walls joined at an angle of less than 180°, such as less than 120°, 90°, 45°, 30°, 15° or 10°. ### Claim 18 (depends on 12) A fluid channel system according to claim 12, wherein each inlet channel comprises a first inlet channel part connecting the inlet and the first droplet formation structure, wherein the first inlet channel part geometry comprise at least two adjacent walls joined at an angle of less than 180°, wherein the inlet channel part longitudinally connects to the inlet. ### Claim 19 (depends on 12) A fluid channel system according to claim 12, wherein the cross-sectional area of the connective channel decreases from the inlets to the fluid collection area. ### Claim 20 (depends on 12) A fluid channel system according to claim 12, wherein the fluid collection area comprises an exit port, wherein the exit port is arranged to allow extraction of fluid collected in the fluid collection area. ### Claim 21 (depends on 12) A fluid channel system according to claim 12, wherein at least a part of a channel has a hydrophilic interior surface. ### Claim 22 (depends on 12) A chip for collecting fluid via at least one microneedle, comprising: at least one microneedle comprising an elongated body extending along a longitudinal axis from a top end to a bottom end and integrally formed on a first side of a substrate, wherein: the elongated body comprises an upper portion and a lower portion; the lower portion of the elongated body comprises an internal capillary bore hole extending into the substrate; the upper portion of the elongated body has a semi-enclosed internal void space formed by at least three body sides whereof two body sides join at a sharp edge and a third body side is provided with an opening slit extending from the lower portion of the elongated body to the upper end of the third body side; the top end of the elongated body is configured as a bevel to create a sharp tip at the top of said edge, said bevel extending to the third body side; the semi-enclosed internal void space of the upper portion of the elongated body opening to the internal capillary bore hole of the bottom end of the elongated body; and the bottom end of the elongated body is connected to the substrate, wherein each proximal end is integrally formed with the substrate and each capillary bore hole is in fluid communication with an inlet of a fluid channel system according to claim 12, on a second side of the substrate, wherein the chip is arranged to, upon a microneedle brought in contact with fluid, passively transport said fluid though said microneedle and the fluid channel system to a fluid collection area. ### Claim 23 (depends on 22) A method of fabricating a chip comprising at least one microneedle and a fluid channel according to claim 22 using a micro electro mechanical system fabrication process, the method comprising: growing a sacrificial oxide layer on a silicon wafer substrate; masking the sacrificial oxide layer with a patterned photoresist; removing the sacrificial oxide layer according to the patterned photoresist; etching the silicon wafer according to the pattern of the removed sacrificial oxide layer using a deep reactive ion etching method; removing the remaining sacrificial oxide layer by using an etchant.