African swine fever virus chimeric protein, vaccine composition, preparation method and use thereof
AssigneePulike Biological Engineering, Inc.
InventorsKegong Tian, Wenqiang Pang, Xuke Zhang
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Abstract
Provided is an African swine fever virus chimeric protein. The chimeric protein comprises: (1) an African swine fever virus p72 domain I; (2) an African swine fever virus p72 domain II; (3) an African swine fever virus p72 domain III; and (4) an African swine fever virus antigenic protein. By using African swine fever virus p72 protein as a skeleton, the chimeric protein provided in the present invention will exhibit antigenic epitopes of African swine fever virus antigenic proteins p54, p30, CD2v, and p12, achieve a good immune effect, and can produce significant humoral and cell-mediated immune response.
Claims13
An African swine fever virus chimeric protein comprising:
- a. African swine fever virus p72 domain I, with an amino acid sequence as shown in SEQ ID NO.2;
- b. African swine fever virus p72 domain II, with an amino acid sequence as shown in SEQ ID NO.3;
- c. African swine fever virus p72 domain III, with an amino acid sequence as shown in SEQ ID NO. 4;
- and
- d. African swine fever virus antigenic protein;
- e. the African swine fever virus p72 domain I is located at the N-terminus of the chimeric protein, the African swine fever virus p72 domain III is located at the C-terminus of the chimeric protein, and the African swine fever virus p72 domain II is located between the domain I and the domain III, the African swine fever virus antigenic protein is located between the domain I and the domain II and/or between the domain II and the domain III.
Dependencies are inferred from the claim text.