Durable vaccination
AssigneeGritstone Bio, Inc.
InventorsKarin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
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Abstract
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
Claims25
A method for stimulating an immune response in a subject, the method comprising administering to the subject a composition for delivery of a self-replicating alphavirus-based expression system and administering to the subject a composition for delivery of a chimpanzee adenovirus (ChAdV)-based expression system, and
- wherein the composition for delivery of the ChAdV-based expression system is administered as a priming dose and the composition for delivery of the self-replicating alphavirus-based expression system is administered as one or more boosting doses, and wherein at least one period between doses is greater than 1 year.
A method for stimulating an immune response in a subject, the method comprising administering to the subject a composition for delivery of a self-replicating alphavirus-based expression system, wherein the composition for delivery of the self-replicating alphavirus-based expression system is administered as one or more doses, and wherein at least one period between doses is greater than 1 year.
8-20. (canceled)
22-39. (canceled)
41-95. (canceled)
97-113. (canceled)
115-186. (canceled)
188-197. (canceled)
Dependencies are inferred from the claim text.