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US 2023/0039639 A1Published application
Generation of acyl alcohols
AssigneeModular Genetics, Inc.
InventorKevin A. Jarrell
Life of this patent
Estimating the term…
Abstract
Methods, compositions, and cells for generating acyl alcohols. Compositions comprising acyl alcohols. Methods of cleaving acyl amino acids and/or acyl alcohols to generate free fatty acids, free amino acids, and/or free alcohols.
Claims21
1-37. (canceled)
An engineered microbial cell comprising one or more polypeptides collectively comprising:
- a fatty acid linkage domain, a peptide synthetase domain, and one or more reductase polypeptides,
- which fatty acid linkage domain is covalently linked to the peptide synthetase domain,
- which fatty acid linkage domain and peptide synthetase domain collectively can produce an acyl amino acid,
- and which one or more reductase polypeptides are collectively capable of reducing the acyl amino acid to an acyl amino alcohol.
1 more element
A method comprising steps of:
- providing an acyl amino acid;
- and
- treating the acyl amino acid with a reductase polypeptide so that an acyl alcohol is released.
A method comprising steps of
- providing an acyl amino acid and/or acyl alcohol;
- and
- treating the acyl amino acid or acyl alcohol so that i) free fatty acid and ii) free amino acid and/or free alcohol is released.
Dependencies are inferred from the claim text.