Devices and methods for reducing rejection of a transplanted organ in a recipient

A method of treating or preventing primary graft dysfunction of a transplanted organ in a recipient of the transplanted organ, the method comprising contacting blood from the recipient with an extracorporeal membrane defining a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory molecules in the blood to pass through the pores for removal from the blood, whereupon the blood depleted of the inflammatory molecules is returned to the recipient.

A method of treating or preventing acute rejection of a transplanted organ by a recipient of the transplanted organ, the method comprising contacting blood from the recipient with an extracorporeal membrane defining a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory molecules in the blood to pass through the pores for removal from the blood, whereupon the blood depleted of the inflammatory molecules is returned to the recipient.

A method of treating or preventing delayed graft function of a transplanted organ in a recipient of the transplanted organ, the method comprising contacting blood from the recipient with an extracorporeal membrane defining a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory molecules in the blood to pass through the pores for removal from the blood, whereupon the blood depleted of the inflammatory molecules is returned to the recipient.

A method of achieving a clinical endpoint indicative of a successful organ transplant in a recipient of a transplanted organ, the method comprising contacting blood from the recipient with an extracorporeal membrane defining a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory molecules in the blood to pass through the pores for removal from the blood, whereupon the blood depleted of the inflammatory molecules is returned to the recipient.

A method of removing inflammatory molecules from the blood of a recipient of a transplanted organ, the method comprising contacting blood from the recipient with an extracorporeal membrane defining a plurality of pores having an average pore size of at least 60 kDa to permit inflammatory molecules in the blood to pass through the pores for removal from the blood, whereupon the blood depleted of the inflammatory molecules is returned to the recipient.

A method of improving a function of a transplanted organ in a recipient of the transplanted organ, the method comprising passing blood from the recipient through an extracorporeal cartridge comprising a housing and a plurality of semi-permeable hollow fibers disposed therein, each of the semi-permeable hollow fibers defining a lumen and a plurality of pores, such that when the blood traverses the lumens of the hollow fibers, inflammatory molecules from the blood pass through the pores and are removed from the blood, whereupon the blood depleted of inflammatory molecules is returned to the recipient, wherein the blood from the recipient is passed through the cartridge during and/or after the transplant of the organ to the recipient.

A method of treating or preventing primary graft dysfunction of a transplanted organ in a recipient of the transplanted organ, the method comprising passing blood from the recipient through an extracorporeal cartridge comprising a housing and a plurality of semi-permeable hollow fibers disposed therein, each of the semi-permeable hollow fibers defining a lumen and a plurality of pores, such that when the blood traverses the lumens of the hollow fibers, inflammatory molecules from the blood pass through the pores and are removed from the blood, whereupon the blood depleted of inflammatory molecules is returned to the recipient, wherein the blood from the recipient is passed through the cartridge during and/or after the transplant of the organ to the recipient.

A method of treating or preventing acute rejection of a transplanted organ by a recipient of the transplanted organ, the method comprising passing blood from the recipient through an extracorporeal cartridge comprising a housing and a plurality of semi-permeable hollow fibers disposed therein, each of the semi-permeable hollow fibers defining a lumen and a plurality of pores, such that when the blood traverses the lumens of the hollow fibers, inflammatory molecules from the blood pass through the pores and are removed from the blood, whereupon the blood depleted of inflammatory molecules is returned to the recipient, wherein the blood from the recipient is passed through the cartridge during and/or after the transplant of the organ to the recipient.

A method of treating or preventing delayed graft function of a transplanted organ in a recipient of the transplanted organ, the method comprising passing blood from the recipient through an extracorporeal cartridge comprising a housing and a plurality of semi-permeable hollow fibers disposed therein, each of the semi-permeable hollow fibers defining a lumen and a plurality of pores, such that when the blood traverses the lumens of the hollow fibers, inflammatory molecules from the blood pass through the pores and are removed from the blood, whereupon the blood depleted of inflammatory molecules is returned to the recipient, wherein the blood from the recipient is passed through the cartridge during and/or after the transplant of the organ to the recipient.

A method of achieving a clinical endpoint indicative of a successful organ transplant in a recipient of a transplanted organ, the method comprising passing blood from the recipient through an extracorporeal cartridge comprising a housing and a plurality of semi-permeable hollow fibers disposed therein, each of the semi-permeable hollow fibers defining a lumen and a plurality of pores, such that when the blood traverses the lumens of the hollow fibers, inflammatory molecules from the blood pass through the pores and are removed from the blood, whereupon the blood depleted of inflammatory molecules is returned to the recipient, wherein the blood from the recipient is passed through the cartridge during and/or after the transplant of the organ to the recipient.

A method of removing inflammatory molecules from the blood of a recipient of a transplanted organ, the method comprising passing blood from the recipient through an extracorporeal cartridge comprising a housing and a plurality of semi-permeable hollow fibers disposed therein, each of the semi-permeable hollow fibers defining a lumen and a plurality of pores, such that when the blood traverses the lumens of the hollow fibers, inflammatory molecules from the blood pass through the pores and are removed from the blood, whereupon the blood depleted of inflammatory molecules is returned to the recipient, wherein the blood from the recipient is passed through the cartridge during and/or after the transplant of the organ to the recipient.