Coated Substrate for Biological Reaction Systems
AssigneeLife Technologies Corporation
InventorsEliodor GHENCIU, Theodore E. STRAUB, Evan W. FOSTER, Michael C. PALLAS
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Abstract
An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
Claims17
A method for designing a substrate with a plurality of reaction sites, the method comprising:
- determining an advancing water contact angle of a liquid sample with a coating material;
- determining a water contact angle for the liquid sample with the coating material;
- and
- if the water contact angle is within 15 degrees of the advancing water contact angle, coating a surface of the substrate and a surface of each reaction site of the plurality of reaction sites with the coating material.
Dependencies are inferred from the claim text.