Antimicrobial compositions
AssigneeOxy Solutions AS
InventorsHege UGLAND, Maja KNUTSEN, Gary Chinga CARRASCO
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Abstract
The invention provides antimicrobial compositions comprising charged cellulose nanofibrils dispersed in an aqueous solution having a dissolved oxygen content of at least 20 mg/L, preferably from 20 to 100 mg/L. The cellulose nanofibrils may have an increased surface charge due to their carboxylic acid content which contributes to their antimicrobial properties. In particular, the carboxylic acid content may be at least about 1000 μmol/g cellulose, preferably at least about 1400 μmol/g cellulose. The compositions are suitable for use in the treatment of wounds, in particular chronic wounds.
Claims24
An antimicrobial composition comprising charged cellulose nanofibrils dispersed in an aqueous solution, wherein said solution has a dissolved oxygen content of at least 20 mg/l.
A composition as claimed in any one of the preceding claims, wherein said charged cellulose nanofibrils are negatively charged.
A composition as claimed in any one of the preceding claims, wherein said charged cellulose nanofibrils are surface-oxidised, preferably TEMPO-oxidised.
A composition as claimed in any one of the preceding claims, wherein the charged cellulose nanofibrils are obtained from wood pulp, preferably softwood pulp, e.g. from Pinus radiata.
A composition as claimed in any one of the preceding claims, wherein the average diameter of the cellulose nanofibrils is in the range from 3 to 20 nm and/or wherein the average length of the cellulose nanofibrils is in the range from 5 to 10 μm.
A composition as claimed in any one of the preceding claims, wherein said solution has a dissolved oxygen content of from 20 to 100 mg/L oxygen, from 20 to 70 mg/L, from 20 to 60 mg/L, from 25 to 50 mg/L, or from 30 to 40 mg/L.
A composition as claimed in any one of the preceding claims which further comprises one or more active substances selected from the group consisting of:
- antibacterial agents, antifungal agents, antiviral agents, antibiotics, growth factors, cytokines, chemokines, nucleic acids, vitamins, minerals, anaesthetics, anti-inflammatory agents, moisturizers, extracellular matrix proteins, enzymes, stem cells from plants, extracts from eggs and eggshells, botanical extracts, fatty acids, and skin penetration enhancers.
A wound dressing in the form of a hydrogel comprising charged cellulose nanofibrils, wherein said hydrogel has a dissolved oxygen content of at least 20 mg/l.
A kit for use in treating a wound, the kit comprising:
- (a) a sterilised, sealed container or package containing an aerogel comprising charged cellulose nanofibrils;
- (b) an oxygenated aqueous liquid (e.g. oxygenated water or oxygenated saline) having a dissolved oxygen content of at least 20 mg/l;
- and
- optionally (c) printed instructions for mixing of the components whereby to form an oxygenated hydrogel and its use in the treatment of a wound.
Dependencies are inferred from the claim text.