Use of itaconate and its derivatives/analogues to induce hair growth
AssigneeThe Johns Hopkins University
InventorsLuis Garza, Mohameed Islam, Barbara Slusher, Rana Rais
Life of this patent
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Abstract
Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed.
Claims22
A method for inducing hair growth or treating an inflammatory skin condition, or immune activation condition (adaptive or innate), or other condition associated with hair loss in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I):
- wherein:
- R1 and R2 can be the same or different and are each independently selected from one or more of the following and combinations thereof:
- (a) —OR3 , wherein R3 is H or C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- (b)
- wherein n is an integer selected from 1, 2, 3, and 4;
- R4 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl or —OR5, wherein R5 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- (c)
- wherein m is an integer selected from 1, 2, 3, and 4;
- p is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, and 20;
- and R6 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- (d)
- wherein R7 is selected from:
- (i) —C(═O)—O—R8 , wherein R8 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- (ii)
- wherein R9 is H or C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- R10 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R11 and R12 are each independently H or a protecting group;
- and R13 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- (iii)
- wherein q is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
- R11 and R12 are each independently H or a protecting group;
- R14 is H or C1-C4 straightchain or branched unsubstituted or substituted alkyl;
- and R15 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- and
- (iv)
- wherein R16 and R17 are each independently selected from H, C1-C4 straight-chain or branched unsubstituted or substituted alkyl, and a protecting group;
- R18 is aryl;
- (e)
- wherein R19 is C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- (f)
- wherein u is an integer selected from 1, 2, 3, and 4;
- R20 is H or C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- and R21 is —OR22, wherein R22 is C1-C6 straightchain or branched unsubstituted or substituted alkyl or —NR23R24, wherein R23 and R24 are each independently H or C1-C4 straightchain or branched unsubstituted or substituted alkyl;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.