Back to results
US 2023/0019129 A1Published application
Hepatitis b core protein allosteric modulators
AssigneesIndiana University Research and Technology Corporation, Assembly Biosciences, Inc.
InventorsWilliam W. Turner, JR., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
Life of this patent
Estimating the term…
Abstract
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
Claims15
1-69. (canceled)
A compound of Formula 7:
- or a pharmaceutically acceptable salt thereof,
- wherein
- Y is S(O)y, wherein y is 2;
- each of Rm and Rm′ independently is selected from the group consisting of H, halogen, C1-6 alkyl (optionally substituted by one, two or three substituents each independently selected from halogen and hydroxyl), C2-6 alkenyl (optionally substituted by one, two or three substituents each independently selected from halogen and hydroxyl), NR′R″, and hydroxyl;
- Rc is H or C1-6 alkyl;
- each of R4, R5, R6, R7, R8, R9, and R10 independently is selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, halogen, hydroxyl, nitro, cyano, and NR′R″;
- R78 is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, NR′R″, —C(O)—C1-6 alkyl, —C(O)—C1-6 alkoxy, phenyl, heteroaryl, C3-6 cycloalkyl, —S(O)w-C1-6 alkyl (where w is 1, 2 or 3), —S(O)w-NR′R″ (where w is 1, 2 or 3), and —NR′—S(O)w, (where w is 1, 2 or 3);
- R79 is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, NR′R″, —C(O)—C1-6 alkyl, —C(O)—C1-6 alkoxy, phenyl, heteroaryl, C3-6 cycloalkyl, —S(O)w-C1-6 alkyl (where w is 1, 2 or 3), —S(O)w-NR′R″ (where w is 1, 2 or 3), and —NR′—S(O)w, (where w is 1, 2 or 3);
- each R′ independently is selected from the group consisting of H, methyl, ethyl, and propyl;
- each R″ is independently selected from H, methyl, ethyl, propyl, butyl, —C(O)-methyl and —C(O)-ethyl, or R′ and R″ taken together with the nitrogen to which they are attached may form a 4-6 membered heterocycle;
- and
- for each occurrence, C1-6 alkyl may be optionally substituted with one, two, or three halogens.
9 more elements
Dependencies are inferred from the claim text.