Exosomes-based therapy for liver fibrosis and other diseases with fibrosis
AssigneeBoard of Regents, The University of Texas System
InventorRaghu KALLURI
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Abstract
Provided herein are compositions of lipid-based nanoparticles, such as exosomes, that contain a therapeutic STAT3-targeting inhibitory RNA. Also provided are methods of using such compositions to treat a patient having fibrosis or a disease associated with fibrosis.
Claims83
A composition comprising a lipid-based nanoparticle that contains an inhibitory RNA that hybridizes to a STAT3 polynucleotide.
A composition comprising a lipid-based nanoparticle that contains an inhibitory RNA that hybridizes to a STAT3 polynucleotide.
A method of preparing a therapeutic composition comprising introducing an inhibitory RNA that hybridizes to a STAT3 polynucleotide into a lipid-based nanoparticle.
Dependencies are inferred from the claim text.