Hyaluronidase compositions and methods of using same to treat peri-orbital hollowness and tear through deformities
AssigneeStandard of Care Corporation
InventorsIliana E. SWEIS, Bryan C. CRESSEY
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Abstract
The present disclosure generally relates to methods and compositions comprising a protein having hyaluronidase activity to diagnose the etiology of, minimize, and treat peri-orbital hollowness with or without associated thyroid disease and to treat tear trough deformity.
Claims99
A method for minimizing peri-orbital hollowness from surgical resection of one or more peri-orbital fat pads in a subject, the method comprising:
- a. administering a composition that comprises a protein having hyaluronidase activity to the peri-orbital region of the subject;
- b. assessing the peri-orbital region at a predetermined amount of time after administration of the composition;
- and
- c. determining an amount of fat to surgically resect from the one or more eyelid fat pads.
A method for determining an amount of fat to be resected surgically from one or more per-orbital fat pads, the method comprising:
- administering a composition that comprises a protein having hyaluronidase activity to the peri-orbital region of the subject having peri-orbital puffiness;
- and
- determining an amount of fat to surgically resect from the one or more fat pads at a predetermined amount of time after administration of the composition.
A method for surgically resecting one or more eyelid fat pads, the method comprising:
- a. administering a composition that comprises a protein having hyaluronidase activity to the peri-orbital region of the subject;
- b. assessing the peri-orbital region at a predetermined amount of time after administration of the composition;
- c. determining an amount of fat to surgically resect from the one or more eyelid fat pads;
- and
- d. resecting a portion of the one or more eyelid fat pads.
A method for diagnosing an etiology of upper and/or lower eyelid puffiness, the method comprising:
- a. examining a subject with squinted eyes;
- and
- b. determining if upper and/or lower eyelid puffiness does not improve, improves, partially improves, or worsens, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be anterior to the orbicularis oculi muscle if the puffiness does not improve, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be posterior to the orbicularis oculi muscle if the puffiness improves, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be anterior and posterior to the orbicularis oculi muscle if the puffiness partially improves, or wherein the puffiness is diagnosed to be secondary to hypertrophy of the orbicularis muscle or if the puffiness worsens.
A method for determining an etiology of peri-orbital puffiness, the method comprising:
- performing an eyelid squint test;
- and
- observing an impact of a movement of an orbicularis oculi muscle on protrusion of eyelid fat pads, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be anterior to the orbicularis oculi muscle if the puffiness does not improve, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be posterior to the orbicularis oculi muscle if the puffiness improves, wherein the etiology of the upper and/or lower eyelid puffiness is diagnosed to be anterior and posterior to the orbicularis oculi muscle if the puffiness partially improves, or wherein the puffiness is diagnosed to be secondary to hypertrophy of the orbicularis muscle or if the puffiness worsens.
A method for determining if a subject with peri-orbital fullness is a candidate for treatment with a glycosaminoglycan based dermal filler along a depressed tear trough, the method comprising:
- a. administering a composition that comprises a protein having hyaluronidase activity to the peri-orbital region of the subject;
- b. assessing the peri-orbital region of the subject at a predetermined period of time after administration of the composition;
- and
- c. determining if there is an improvement in the peri-orbital fullness,
- wherein the subject is a candidate for treatment with the glycosaminoglycan based dermal filler along the depressed tear trough where the subject does not exhibit an improvement in peri-orbital fullness after administration of the composition.
A method for treating a subject having peri-orbital fullness and a depressed tear trough, the method comprising:
- a. administering a composition that comprises a protein having hyaluronidase activity to the peri-orbital region of the subject;
- b. assessing the peri-orbital region of the subject at a predetermined period of time after administration of the composition;
- c. determining if there is an improvement in the peri-orbital fullness;
- and
- d. injecting a glycosaminoglycan based filler to and area of skin having the depressed tear trough if the subject does not exhibit an improvement in peri-orbital fullness after administration of the composition.
A method of treating peri-orbital edema associated with a thyroid disease in a subject in need thereof, the method comprising administering a composition that comprises a protein having hyaluronidase activity to a peri-orbital region of the subject.
A method of reducing peri-orbital edema associated with a thyroid disease in a subject in need thereof, the method comprising administering a composition that comprises a protein having hyaluronidase activity to a peri-orbital region or to an eyeball of the subject, wherein the administration of the composition reduces amount of the peri-orbital edema.
Dependencies are inferred from the claim text.