US 2022/0411804 A1Published application

Pikfyve antisense oligonucleotides

AssigneeAcurastem Incorporated

InventorsWen-Hsuan Chang, Emily Elizabeth Lee

Life of this patent

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Abstract

The present invention relates to PIKFYVE antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Claims44

Dependent claims

A single stranded antisense oligonucleotide that suppresses the expression of a PIKFYVE, wherein the antisense oligonucleotide has a nucleobase sequence that comprises at least 12 or 15 consecutive nucleobases of any of the nucleobase sequences of SEQ ID NO:

1-500.

Dependencies are inferred from the claim text.

Facts

Application: 17/808,247Filed 22 Jun 2022
Priority: 22 Jun 2021
Published: 29 Dec 2022
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
A61K 31/7115
Compounds having three or more nucleosides or nucleotides: nucleic acids or oligonucleotides having modified bases, i.e. other than adenine,…
A61K 31/712
Compounds having three or more nucleosides or nucleotides: nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or…
A61K 31/7125
Compounds having three or more nucleosides or nucleotides: nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other…

Family

Application63/202,717Us provisional application · filed 22 Jun 2021
US 12,104,159 B2Related patent
US 2022/0411804 A1This patent

From the US filing history. Foreign family members aren’t listed.

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