Proteins comprising cd3 antigen binding domains and uses thereof
AssigneeJanssen Biotech, Inc.
InventorsRaymond Brittingham, Scott R. Brodeur, Rajkumar Ganesan, Jaclyn Hoover, Steven A. Jacobs, Colleen M. Kane, Jinquan Luo, Sanjaya Singh, Fang Yi, Adam Zwolak, Triveni K. Bhatt, Michael Dennis Feldkamp, Sherry Lynn La Porte
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Abstract
The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.
Claims68
An isolated protein comprising an antigen binding domain that binds to cluster of differentiation 3ε (CD3ε), wherein the antigen binding domain that binds CD3ε comprises:
- a. a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 of a heavy chain variable region (VH) of SEQ ID NO:
- 23 and a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3 of a light chain variable region (VL) of SEQ ID NO:
- 24;
- b. the HCDR1, the HCDR2 and the HCDR3 of the VH of SEQ ID NO:
- 23 and the LCDR1, the LCDR2 and the LCDR3 of the VL of SEQ ID NO:
- 27;
- c. the HCDR1, the HCDR2 and the HCDR3 of the VH of SEQ ID NO:
- 23 and the LCDR1, the LCDR2 and the LCDR3 of the VL of SEQ ID NO:
- 28;
- d. the HCDR1, the HCDR2 and the HCDR3 of the VH of SEQ ID NO:
- 23 and the LCDR1, the LCDR2 and the LCDR3 of the VL of SEQ ID NO:
- 29;
- or
- e. the HCDR1, the HCDR2 and the HCDR3 of the VH of SEQ ID NO:
- 23 and the LCDR1, the LCDR2 and the LCDR3 of the VL of SEQ ID NO:
- 30.
An isolated protein comprising an antigen binding domain that binds CD3ε, wherein the antigen binding domain that binds CD3ε comprises a heavy chain variable region (VH) of SEQ ID NO:
- 23 and a light chain variable region (VL) of SEQ ID NO:
- 103.
An isolated protein comprising an antigen binding domain that binds to an epitope on CD3ε (SEQ ID NO:
- 1), wherein the epitope is a discontinuous epitope comprising the amino acid sequences of SEQ ID NO:
- 100, 101, and 102.
Dependencies are inferred from the claim text.