Methods of Preparing Primary Phosphine Products Using Lewis Acid Catalysts
AssigneeUniversity of Vermont and State Agricultural College
InventorsRory Waterman, Brandon Ackley
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Abstract
Methods of preparing primary phosphine products using one or more precursor cyclophosphanes, hydrogen, and one or more Lewis acid catalysts. In some embodiments, a cyclophosphane precursor and at least one Lewis acid are dissolved in a solvent to provide a solution. The solution is treated with hydrogen, and optionally heated, to cause a reaction that produces a primary phosphine © product. The primary phosphine product may be isolated from the Lewis acid(s) and optionally purified. In some embodiments, a method may include synthesizing the cyclophosphane precursor prior to mixing the cyclophosphane precursor and the Lewis acid(s).
Claims48
A method of preparing a primary phosphine product, comprising:
- providing a precursor comprising a cyclophosphane with the general formula (R-P)n, where R is any organic functional group;
- mixing a Lewis acid with the precursor to provide a mixture;
- treating the mixture of the precursor and the Lewis acid with hydrogen under reaction conditions suitable for forming the primary phosphine product from the mixture;
- and
- separating the Lewis acid from the primary phosphine product so as to isolate the primary phosphine product.
A method of preparing a primary phosphine product, comprising:
- providing a precursor comprising a cyclophosphane with the general formula (R-P)a, where R is any organic functional group;
- mixing a Lewis acid with the precursor and a solvent to provide a solution;
- treating the solution of the precursor and the Lewis acid with hydrogen;
- heating the hydrogen and the mixture of the precursor and the Lewis acid;
- and
- removing the Lewis acid and the solvent so as to isolate the primary phosphine product.
A method of preparing a primary phosphine product, comprising:
- providing a precursor with the general formula R-P-X2, where R is an organic functional group and X is a halogen;
- reacting the precursor with a dehalogenating agent so as to remove both halogens X and form a cyclophosphane of the general formula (R-P)n;
- mixing a Lewis acid with the cyclophosphane to create a mixture;
- contacting the mixture of the cyclophosphane and the Lewis acid with hydrogen gas;
- heating the hydrogen gas and the mixture of the cyclophosphane and the Lewis acid;
- and
- removing the Lewis acid to isolate the primary phosphine product.
Dependencies are inferred from the claim text.