Compositions and methods for the prophylaxis and treatment of babesiosis
AssigneeTufts Medical Center, Inc.
InventorsEdouard VANNIER, Joseph J. CAMPO, JR.
Life of this patent
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Abstract
Described herein are compositions that comprise one or more Babesia microti antigens, one or more Babesia microti nucleic acid molecules, or one or more anti-Babesia microti antibodies and uses thereof in methods for the prophylaxis of babesiosis, the treatment of babesiosis and the monitoring of individuals undergoing prophylactic or therapeutic administration of the compositions of the invention.
Claims25
A composition selected from the group consisting of compositions 1-112 of Tables 2-9, wherein the composition comprises each of the Bm antigens indicated as being present in the composition or one or more antigenic variants and/or antigenic fragments thereof.
A composition comprising:
- a Bm antigen of SEQ ID NO:
- 49, or an antigenic variant and/or antigenic fragment thereof;
- a Bm antigen of SEQ ID NO:
- 50, or an antigenic variant and/or antigenic fragment thereof;
- a Bm antigen of SEQ ID NO:
- 51, or an antigenic variant and/or antigenic fragment thereof;
- a Bm antigen of SEQ ID NO:
- 52, or an antigenic variant and/or antigenic fragment thereof;
- a Bm antigen of SEQ ID NO:
- 53, or an antigenic variant and/or antigenic fragment thereof;
- and/or a Bm antigen of SEQ ID NO:
- 54, or an antigenic variant and/or antigenic fragment thereof;
- or two or more of said Bm antigens, or antigenic variants and/or antigenic fragments thereof.
(canceled)
(canceled)
15-20. (canceled)
22-23. (canceled)
A kit comprising (a) two or more Bm antigens comprising an amino acid sequence having at least 80%, 85%, 90%, 92%, 95%, 97%, 98%, 99%, sequence identity to the amino acid sequence of any one of SEQ ID NOs:
- 1-24 or 49-54, or one or more antigenic fragments thereof, wherein two or more Bm antigens are immobilized on one or more solid supports;
- (b) an antibody detection reagent;
- and (c) a package insert comprising instructions for using the two or more Bm antigens and the antibody detection reagent in accordance with a method described herein, optionally wherein the kit comprises one or more Bm antigen comprising an amino acid sequence having at least 80% sequence identity to the amino acid sequence of any one of SEQ ID NOs:
- 49-54, or one or more antigenic fragments thereof.
(canceled)
Dependencies are inferred from the claim text.