Methods for reprogramming somatic cells
AssigneeWhitehead Institute for Biomedical Research
InventorsRudolf Jaenisch, Konrad Hochedlinger
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Abstract
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
Claims25
A composition comprising an isolated human somatic cell that comprises an exogenously introduced nucleic acid encoding an OCT4 protein.
A composition comprising an isolated human primary somatic cell that comprises an exogenously introduced nucleic acid encoding an OCT4 protein operably linked to at least one regulatory sequence.
A composition comprising an isolated human somatic cell that comprises an exogenously introduced OCT4 protein and an exogenously introduced SOX2 or NANOG protein.
A human somatic cell comprising an exogenous nucleic acid encoding OCT4 and an amount of OCT4 protein sufficient to make the cell more susceptible to reprogramming.
A composition comprising an isolated human somatic cell that comprises an exogenously introduced polynucleic acid encoding OCT4 protein, and an exogenously introduced polynucleic acid encoding SOX2 or NANOG protein.
Dependencies are inferred from the claim text.