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US 2022/0403047 A1Published application
Antibody specifically recognizing itih1, and pharmaceutical composition containing same for improving insulin resistance in diseases accompanied by impaired glucose tolerance
AssigneeApharma
InventorsSang Geon KIM, Yeonseok CHUNG, Tae Hyun KIM, Won KIM
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Abstract
A pharmaceutical composition for improving insulin sensitivity in diseases accompanied by impaired glucose tolerance is disclosed. The pharmaceutical composition contains an antibody or an antigen-binding fragment thereof that specifically recognizes ITIH1 exhibiting increased expression in diseases accompanying high blood sugar. The pharmaceutical composition can be effectively used for improving insulin sensitivity in various diseases accompanying high blood sugar.
Claims17
An antibody or antigen-binding fragment thereof specifically recognizing an inter-alpha trypsin inhibitor heavy chain 1 (ITIH1),
- wherein the antibody comprises a light-chain variable region comprising complementarity-determining regions CDRL1, CDRL2, and CDRL3 set forth in SEQ ID NOS:
- 1, 2, and 3, respectively, and a heavy-chain variable region comprising complementarity-determining regions CDRH1, CDRH2, and CDRH3 set forth in SEQ ID NOS:
- 4, 5, and 6, respectively, or
- a light-chain variable region comprising complementarity-determining regions CDRL1, CDRL2, and CDRL3 set forth in SEQ ID NOS:
- 7, 8, and 9, respectively, and a heavy-chain variable region comprising complementarity-determining regions CDRH1, CDRH2, and CDRH3 set forth in SEQ ID NOS:
- 10, 11, and 12, respectively.
3 more elements
Dependencies are inferred from the claim text.