Nanotube trans-membrane channels mimicking biological porins
AssigneesLawrence Livermore National Security, LLC, The Regents of the University of California, Universidad Del Pais Vasco
InventorsAleksandr Noy, Jia Geng, Jianfei Zhang, Vadim Frolov
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Abstract
Provided herein is a nanopore structure, which in one aspect is a “carbon nanotube porin”, that comprises a short nanotube with an associated lipid coating. Also disclosed are compositions and methods enabling the preparation of such nanotube/lipid complexes. Further disclosed is a method for therapeutics delivery that involves a drug delivery agent comprising a liposome with a NT loaded with a therapeutic agent, introducing the therapeutic agent into a cell or a tissue or an organism; and subsequent release of the therapeutic agents into a cell.
Claims20
A delivery method, comprising incubating a lipid-coated nanotube with a lipid membrane and thereby inserting the lipid-coated nanotube into the lipid membrane to form a channel across the lipid membrane;
- and delivering a moiety across the lipid membrane through the channel formed by the nanotube.
Dependencies are inferred from the claim text.