Synthetic Antibacterial Compounds and Uses Thereof
AssigneeMcMaster University
InventorsEric Brown, Omar M Elhalfawy, Nick Jentsch, Xiong Zhang, Jakob Magolan
Life of this patent
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Abstract
Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.
Claims25
A compound having the structure of formula (1),
- wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system;
- and
- Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group,
- or a pharmaceutically acceptable salt thereof,
- with the proviso that the compound is not 2-[3,5-dihydroxy-4-(3,7-dimethyl-2,6-octadienyl)phenyl]-6-hydroxybenzofuran.
12-14. (canceled)
A method for inhibiting growth of a bacterium, comprising contacting the bacterium with a compound having the structure of formula (1),
- wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system;
- and
- Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group,
- or a pharmaceutically acceptable salt thereof.
(canceled)
18-28. (canceled)
30-32. (canceled)
39-60. (canceled)
Dependencies are inferred from the claim text.