Injection Systems and Methods of Their Use

A method for treatment of an eye disease, the method comprises:

• pre-inserting into a sclera of a patient a puncture element of an injection system, the injection system comprising:
• a syringe barrel defining a lumen between a proximal end and a distal end;
• a first sealing element moveably disposed within the lumen;
• a second sealing element moveably disposed within the lumen proximal to the first sealing element, wherein the first sealing element and the second sealing element form a seal with the lumen and define an injection chamber between them;
• the puncture element extending from a distal end of the first sealing element, the puncture element being in fluid communication with the injection chamber to deliver an injection agent from the injection chamber into a space in a tissue of a patient;
• and
• wherein one or more of the syringe barrel, the first sealing element, and the second sealing element are configured to prevent proximal movement of the first sealing element past a pre-selected location, while allowing the second sealing element to come in contact with the first sealing element;
• advancing the puncture element through the sclera by applying a force onto the second sealing element, the force being sufficient to move the first sealing element in the distal direction to advance the puncture element in the distal direction, without conveying the injection agent through the puncture element;
• and
• maintaining the force onto the second sliding element as the puncture element passes through the sclera and opens into a suprachoroidal space (SCS) such that the injection agent is conveyed from the injection chamber through the puncture element into the SCS, without further distal movement of the first sealing element.

A kit for injection of an injection agent into a tissue comprising:

• an injection system comprising:
• a syringe barrel defining a lumen between a proximal end and a distal end;
• a first sealing element moveably disposed within the lumen;
• a second sealing element moveably disposed within the lumen proximal to the first sealing element, wherein the first sealing element and the second sealing element form a seal with the lumen and define an injection chamber between them;
• a puncture element extending from a distal end of the first sealing element, the puncture element being in fluid communication with the injection chamber to deliver an injection agent from the injection chamber into a space in a tissue of a patient;
• and
• wherein one or more of the syringe barrel, the first sealing element, and the second sealing element are configured to prevent proximal movement of the first sealing element past a pre-selected location, while allowing the second sealing element to come in contact with the first sealing element, and
• wherein the system is configured such that, when a force is applied on the second sealing element in a distal direction,
• in response to a first opposing force, the first sealing element moves in the distal direction to advance the puncture element in the distal direction, without conveying the injection agent through the puncture element, and
• in response to a second opposing force, the first sealing element remains stationary and the injection agent is conveyed from the injection chamber through the puncture element;
• and
• a volume of the injection fluid comprising one or more injection agent formulations.