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AssigneeUniversity of Utah Research Foundation
InventorsKathryn A. Peterson, Gerald J. Gleich, Mark D. Yandell, Edwin Lin, Hedieh Saffari
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Disclosed are methods of diagnosing and treating a subject with active or inactive eosinophilic esophagitis (EoE). The methods may include the steps of detecting whether a level of one or more immunoglobulin antibodies is elevated in an esophageal secretion sample obtained from a subject, diagnosing the subject with active EoE when the level of one or more immunoglobulin antibodies in the sample is elevated above a pre-determined cut-off value and diagnosing the subject with inactive EoE when the level of one or more immunoglobulin antibodies level in the sample is below a pre-determined cut-off value; and treating the subject diagnosed with active EoE.
A method of detecting the binding of one or more food specific immunoglobulin (Ig) antibodies to one or more food antigens in a sample, the method comprising:
The method of any of the preceding claims, wherein the sample is obtained before the subject consumes a food comprising one or more of the food antigens.
The method of any of the preceding claims, wherein the sample is obtained after the subject consumes a food comprising one or more of the food antigens.
The method of any of the preceding claims, further comprising comparing the binding of the one or more food specific Ig antibodies to the one or more food antigens in the sample obtained prior to the subject consuming the food comprising the one or more of the food antigens to the sample obtained after the subject consumed the food comprising the one or more of the food antigens.
A method of detecting a food specific immune response in a sample, the method comprising:
A method of identifying a food allergy in a subject with active or inactive eosinophilic esophagitis (EoE) in a subject suffering from EoE, the method comprising:
A method of treating a subject with active or inactive eosinophilic esophagitis (EoE) in a subject suffering from EoE, the method comprising:
A method of diagnosing and treating a subject with active or inactive eosinophilic esophagitis (EoE) in a subject suffering from EoE, the method comprising:
The method of any of the preceding claims, further comprising obtaining or have obtained the sample from a subject.
The method of any of the preceding claims, wherein the sample comprises one or more one or more food-specific Ig antibodies.
The method of any of the preceding claims, wherein the sample is a mucosal sample.
The method of any of the preceding claims, wherein the one or more food-specific Ig antibodies are IgG, IgA, IgM, IgD, IgE or a combination thereof.
The method of any of the preceding claims, wherein the one or more food antigens are wheat f1, soybean f14, casein f78, eggf245, or a combination thereof.
A method of detecting the cause of a eosinophilic esophagitis (EoE) symptom, wherein the EoE symptom is caused by an immune response to an antigen in a patient diagnosed with or suffering from EOE, the method comprises:
Dependencies are inferred from the claim text.