Derivatization of beta-lactam antibiotics as calibrators/istd in massspec measurements
AssigneeRoche Diagnostics Operations, Inc.
InventorsFlorian Huber, Thomas Scheidt, Gaston Hubertus Maria Vondenhoff
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Abstract
The invention relates to a complex comprising an antibiotic substance and a nucleophilic derivatization reagent, compositions comprising the complex, kits comprising complex or composition, as well as uses of the complex or composition.
Claims25
1) A complex formed of an antibiotic substance and a nucleophilic derivatization reagent.
9) (canceled)
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13) A derivatized antibiotic substance suitable as an ISTD and/or a calibrator in Mass Spec Measurements.
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15) A method of producing a stabilized antibiotic substance, comprising derivatizing an antibiotic substance with a nucleophilic derivatization reagent to stabilize the antibiotic substance.
Dependencies are inferred from the claim text.