Methods and compositions for generating pacemaker cells
AssigneeYu-Feng Hu
InventorsYu-Feng HU, Tze-Wen CHUNG, Shih-Ann CHEN
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Abstract
Disclosed herein are methods and compositions for generating pacemaker cells from non-pacemaker cardiomyocytes. For example, the method includes the step of culturing the non-pacemaker cardiomyocytes with silk fibroin so that the silk fibroin induces the transformation of at least a portion thereof into pacemaker cells.
Claims19
Pacemaker cells, generated using a method comprising the step of,
- culturing a cell population comprising non-pacemaker cardiomyocytes with an effective amount of a silk fibroin biomaterial so that one or more of the non-pacemaker cardiomyocytes are transformed into the pacemaker cells.
A method for generating pacemaker cells, comprising the step of contacting a cell population comprising non-pacemaker cardiomyocytes with an effective amount of a silk fibroin biomaterial so that one or more of the non-pacemaker cardiomyocytes are transformed into the pacemaker cells.
A method of treating a subject suffering from cardiac arrhythmia, comprising the step of administering to the heart of the subject an effective amount of a silk fibroin biomaterial.
Dependencies are inferred from the claim text.