Compositions and methods for synthesis of terpenoids
OwnerStefan DE KOK, Warren LAU +4inventors
InventorsStefan DE KOK, Warren LAU, Fern MCSORLEY, Hermann-Josef MEYER, Zach SERBER, Grayson WAWRZYN
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Abstract
The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering. In particular, the disclosure relates to the biosynthesis of nepetalactol, nepetalactone, dihydronepetalactone, and derivatives thereof. The disclosure provides recombinant cells genetically engineered to produce high levels of nepetalactol, nepetalactone and/or dihydronepetalactone. The disclosure also provides methods of producing nepetalactol, nepetalactone and dihydronepetalactone using cell-based systems as well as cell-free systems.
Claims26
-137. (canceled)
A recombinant microbial cell capable of producing nepetalactol, wherein the recombinant microbial cell expresses an altered level of an oxidoreductase, as compared to a wild type microbial cell, wherein the oxidoreductase is selected from FMS1, SUR2, SWT21, QCR9, and NCP1.
Dependencies are inferred from the claim text.