Novel compositions for disrupting biofilms
AssigneeThe Trustees of Indiana University
InventorsChandan K. SEN, Subhadip GHATAK
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Abstract
Compositions and methods are provided for disrupting biofilms formed by microbial organisms. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use on chronic wounds. In one embodiment the biofilm disrupting composition comprises a nuclease and aurine tricarboxylic acid. The biofilm disrupting compositions disclosed herein can be used in conjunction with a therapeutic pharmaceutical composition comprising standard antibiotics.
Claims18
A biofilm disrupting composition comprising
- a nuclease;
- a compound that disrupts the binding of nucleic acids to proteins;
- and
- a pharmaceutically acceptable carrier.
A method for disrupting a biofilm, said method comprising contacting the biofilm with a composition comprising a nuclease and aurine tricarboxylic acid (ACA).
Dependencies are inferred from the claim text.