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US 2022/0354929 A1Published application
Peptides and uses thereof
AssigneeLateral IP Pty Ltd
InventorAndrew Gearing
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AssigneeLateral IP Pty Ltd
InventorAndrew Gearing
Estimating the term…
Disclosed herein are methods and compositions for treating or preventing neuropathic pain in a subject, the method comprising administering to a subject a therapeutically effective amount of prolactin, or a functional variant thereof, wherein the functional variant comprises a peptide of formula (I) or a pharmaceutically acceptable salt thereof: R1-C-R-I-X1-X2-X3-X4-N-C-R2 (I) (SEQ ID NO:1) wherein X1 is an amino acid residue selected from isoleucine (I) and valine (V); X2 is an amino acid residue selected from histidine (H) and tyrosine (Y); X3 is an amino acid residue selected from aspartic acid (D) and asparagine (N); X4 is an amino acid Nresidue selected from asparagine (N) and serine (S); R1 is selected from the group consisting of YLKLLK, LKLLK, KLLK, LLK, LL, K or R1 is absent; and R2 is G (glycine), or R2 is absent.
A method of treating or preventing neuropathic pain in a subject, the method comprising administering to a subject a therapeutically effective amount of prolactin, or a functional variant thereof, wherein the functional variant comprises a peptide of formula (I) or a pharmaceutically acceptable salt thereof:
The method of any one of claims 1 to 9, further comprising administering to the subject a therapeutically effective amount of a second agent capable of alleviating pain in the subject, wherein the second agent is not prolactin, or a functional variant thereof according to any one of claims 1 to 10.
A pharmaceutical composition comprising prolactin, or a functional variant thereof, for use in the treatment or prevention of neuropathic pain in a subject, wherein the functional variant comprises a peptide of formula (I):
Use of prolactin, or a functional variant thereof, in the manufacture of a medicament for the treatment or prevention of neuropathic pain in a subject, wherein the functional variant comprises a peptide of formula (I):
A composition comprising a therapeutically effective amount of prolactin-derived peptide consisting of amino acid sequence CRIIHNNNC (SEQ ID NO:2) or amino acid sequence CRIIHNNNCG (SEQ ID NO:3) or amino acid sequence CRIVYDSNC (SEQ ID NO:4) or amino acid sequence CRIVYDSNCG (SEQ ID NO:5).
A composition comprising a peptide of SEQ ID NO:
A pharmaceutical composition comprising:
An analgesic composition comprising prolactin, or a functional variant thereof, wherein the functional variant comprises a peptide of formula (I):
An analgesic composition comprising a therapeutically effective amount of prolactin, or a functional variant thereof, wherein the functional variant consists of amino acid sequence CRIIHNNNC (SEQ ID NO:2) or amino acid sequence CRIIHNNNCG (SEQ ID NO:3) or amino acid sequence CRIVYDSNC (SEQ ID NO:4) or amino acid sequence CRIVYDSNCG (SEQ ID NO:5).
An analgesic composition comprising a peptide selected from the group consisting of any one of SEQ ID NOs:
A pharmaceutical composition comprising prolactin, or a functional variant thereof, wherein the functional variant comprises a peptide of formula (I):
Dependencies are inferred from the claim text.