Il-15 humanized mouse model and use thereof
AssigneeGempharmatech Co., Ltd.
InventorsCunxiang JU, Weiwei YU, Mingkun ZHANG, Hongyan SUN, Dingyu WANG
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Abstract
Provided are a mouse and a functional activity part thereof, comprising a humanized IL-15 gene; the humanized IL-15 gene comprises a human IL-15 gene segment and a mouse IL-15 gene segment, the human IL-15 gene segment comprises at least a part of exon 4, exon 5, exon 6, exon 7 and exon 8 of the human IL-15 gene, and the mouse IL-15 gene segment comprises exon 1, exon 2 and exon 3 of the mouse IL-15 gene. Also provided are a preparation method and use of the mouse.
Claims47
A mouse or a functionally active part thereof, comprising a humanized IL-15 gene, wherein the humanized IL-15 gene comprises a human IL-15 gene segment and a mouse IL-15 gene segment,
- wherein the human IL-15 gene segment comprises at least a part of exon 4, exon 5, exon 6, exon 7, and exon 8 of the human IL-15 gene,
- wherein the mouse IL-15 gene segment comprises exon 1, exon 2 and exon 3 of the mouse IL-15 gene.
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A method for preparing a genetically modified mouse, comprising:
- replacing a mouse IL-15 gene segment encoding a mature mouse IL-15 polypeptide on an endogenous mouse IL-15 locus with a human IL-15 gene segment encoding a mature human IL-15 polypeptide so as to form a humanized IL-15 gene, wherein the human IL-15 gene segment comprises at least a part of exon 4, exon 5, exon 6, exon 7, and exon 8 of the human IL-15 gene.
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Dependencies are inferred from the claim text.